Nat Prod Sci.  2018 Sep;24(3):155-158. 10.20307/nps.2018.24.3.155.

Meliglabrin, A New Flavonol Derivative from the leaves of Melicope glabra (Blume) T.G. Hartley

• Saputri RD
• Srie Tjahjandarie T
• Tanjung M

• KMID: 2422006
• DOI: http://doi.org/10.20307/nps.2018.24.3.155

Abstract

A new flavonol derivative, meliglabrin (1) along with three known flavonols, ternatin (2), meliternatin (3), and 5,4"²-dihydroxy-3,7,3"²-trimethoxyflavon (4) were isolated from the leaves of Melicope glabra (Blume) T.G. Hartley. Their structures were determined using extensive spectroscopic methods, including UV, IR, HRESIMS, 1D and 2D NMR. Compounds 1 - 4 were evaluated for their cytotoxicity against murine leukemia P-388 cells, compound 4 showed moderate activity.

Keyword

Meliglabrin; flavonol, Melicope glabra, P-388 cells

MeSH Terms

Flavonols
Leukemia
Rutaceae*
Flavonols

Figure

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  Fig. 1 Flavonols 1 – 4 isolated from the leaves of M. glabra.

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  Fig. 2 Selected HMBC correlations for compound 1.

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