J Vet Sci.  2018 Sep;19(5):708-715. 10.4142/jvs.2018.19.5.708.

Bee venom stimulation of a lung meridian acupoint reduces inflammation in carrageenan-induced pleurisy: an alternative therapeutic approach for respiratory inflammation

Affiliations
  • 1Department of Veterinary Physiology, BK21 PLUS Program for Creative Veterinary Science Research, Research Institute for Veterinary Science and College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea. yhryu@kiom.re.kr
  • 2KM Fundamental Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Korea. yhryu@kiom.re.kr
  • 3Department of Oral Physiology, School of Dentistry, Kyung Hee University, Seoul 02447, Korea.

Abstract

Respiratory inflammation is a frequent and fatal pathologic state encountered in veterinary medicine. Although diluted bee venom (dBV) has potent anti-inflammatory effects, the clinical use of dBV is limited to several chronic inflammatory diseases. The present study was designed to propose an acupoint dBV treatment as a novel therapeutic strategy for respiratory inflammatory disease. Experimental pleurisy was induced by injection of carrageenan into the left pleural space in mouse. The dBV was injected into a specific lung meridian acupoint (LU-5) or into an arbitrary non-acupoint located near the midline of the back in mouse. The inflammatory responses were evaluated by analyzing inflammatory indicators in pleural exudate. The dBV injection into the LU-5 acupoint significantly suppressed the carrageenan-induced increase of pleural exudate volume, leukocyte accumulation, and myeloperoxidase activity. Moreover, dBV acupoint treatment effectively inhibited the production of interleukin 1 beta, but not tumor necrosis factor alpha in the pleural exudate. On the other hand, dBV treatment at non-acupoint did not inhibit the inflammatory responses in carrageenan-induced pleurisy. The present results demonstrate that dBV stimulation in the LU-5 lung meridian acupoint can produce significant anti-inflammatory effects on carrageenan-induced pleurisy suggesting that dBV acupuncture may be a promising alternative medicine therapy for respiratory inflammatory diseases.

Keyword

acupuncture; anti-inflammation; bee venoms; carrageenan-induced pleurisy

MeSH Terms

Acupuncture
Acupuncture Points*
Animals
Bee Venoms*
Bees*
Carrageenan
Complementary Therapies
Exudates and Transudates
Hand
Inflammation*
Interleukin-1beta
Leukocytes
Lung*
Mice
Peroxidase
Pleurisy*
Tumor Necrosis Factor-alpha
Veterinary Medicine
Bee Venoms
Carrageenan
Interleukin-1beta
Peroxidase
Tumor Necrosis Factor-alpha
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