J Vet Sci.  2018 Sep;19(5):585-591. 10.4142/jvs.2018.19.5.585.

Health and temperaments of cloned working dogs

Affiliations
  • 1Department of Theriogenology and Biotechnology, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea. bclee@snu.ac.kr
  • 2Haemaru Referral Animal Hospital and Small Animal Clinical Research Institute, Seongnam 13590, Korea.
  • 3Animal Biotechnology Division, National Institute of Animal Science, Rural Development Administration, Jeonju 54875, Korea.

Abstract

Dogs serve human society in various ways by working at tasks that are based on their superior olfactory sensitivity. However, it has been reported that only about half of all trained dogs may qualify as working dogs through conventional breeding management because proper temperament and health are needed in addition to their innate scent detection ability. To overcome this low efficiency of breeding qualified working dogs, and to reduce the enormous costs of maintaining unqualified dogs, somatic cell nuclear transfer has been applied in the propagation of working dogs. Herein, we review the history of cloning working dogs and evaluate the health development, temperaments, and behavioral similarities among the cloned dogs. We also discuss concerns about dog cloning including those related to birth defects, lifespan, and cloning efficiency.

Keyword

behavior; cloning; health; working dog

MeSH Terms

Animals
Breeding
Clone Cells*
Cloning, Organism
Congenital Abnormalities
Dogs*
Humans
Temperament*

Figure

  • Fig. 1 Birth weight (A) and growth performance (B) of cloned working dogs from birth up to 6 weeks old. Cloned Belgian Malinois (○, n = 4), Labrador Retriever (●, n = 23), German Shepherd (Δ, n = 11), and Springer Spaniel (▲, n = 9) dogs were analyzed.


Reference

1. Asher L, Blythe S, Roberts R, Toothill L, Craigon PJ, Evans KM, Green MJ, England GCW. A standardized behavior test for potential guide dog puppies: methods and association with subsequent success in guide dog training. J Vet Behav. 2013; 8:431–438.
Article
2. Bartlett M. A novice looks at puppy aptitude testing. Am Kennel Gaz. 1979; 31–42.
3. Branson N, Cobb M, McGreevy P. Australian working dog survey report 2009. Canberra: Australian Government Department of Agriculture, Fisheries and Forestry;2010.
4. Campbell WE. A behavior test for puppy selection. Mod Vet Pract. 1972; 12:29–33.
5. Cheung CH, Wood AC, Paloyelis Y, Arias-Vasquez A, Buitelaar JK, Franke B, Miranda A, Mulas F, Rommelse N, Sergeant JA, Sonuga-Barke EJ, Faraone SV, Asherson P, Kuntsi J. Aetiology for the covariation between combined type ADHD and reading difficulties in a family study: the role of IQ. J Child Psychol Psychiatry. 2012; 53:864–873.
Article
6. Choi J, Kim HB, Kang YU, Kim MJ, Lee SI, Oh HJ, Kim GA, Jo YK, Park EJ, Park JY, Choi YG, Lee BC. Personality consistency analysis in cloned quarantine dog candidates. Acta Vet Brno. 2017; 86:273–283.
Article
7. Choi J, Lee JH, Oh HJ, Kim MJ, Kim GA, Park EJ, Jo YK, Lee SI, Hong DG, Lee BC. Behavioral analysis of cloned puppies derived from an elite drug-detection dog. Behav Genet. 2014; 44:68–76.
Article
8. Choi YB, Kim GA, Oh HJ, Kim MJ, Jo YK, Setyawan EM, Lee SH, Lee BC. Cloning of the short-tailed Gyeongju Donggyeong dog via SCNT: conserving phenotypic inheritance. J Vet Med Sci. 2016; 78:329–331.
Article
9. Cibelli JB, Stice SL, Golueke PJ, Kane JJ, Jerry J, Blackwell C, Ponce de León FA, Robl JM. Cloned transgenic calves produced from nonquiescent fetal fibroblasts. Science. 1998; 280:1256–1258.
Article
10. Cornu JN, Cancel-Tassin G, Ondet V, Girardet C, Cussenot O. Olfactory detection of prostate cancer by dogs sniffing urine: a step forward in early diagnosis. Eur Urol. 2011; 59:197–201.
Article
11. Denning C, Burl S, Ainslie A, Bracken J, Dinnyes A, Fletcher J, King T, Ritchie M, Ritchie WA, Rollo M, de Sousa P, Travers A, Wilmut I, Clark AJ. Deletion of the alpha(1,3)galactosyl transferase (GGTA1) gene and the prion protein (PrP) gene in sheep. Nat Biotechnol. 2001; 19:559–562.
Article
12. Ehmann R, Boedeker E, Friedrich U, Sagert J, Dippon J, Friedel G, Walles T. Canine scent detection in the diagnosis of lung cancer: revisiting a puzzling phenomenon. Eur Respir J. 2012; 39:669–676.
Article
13. Ennik I, Liinamo AE, Leighton E, van Arendonk J. Suitability for field service in 4 breeds of guide dogs. J Vet Behav. 2006; 1:67–74.
Article
14. Foyer P, Bjällerhag N, Wilsson E, Jensen P. Behaviour and experiences of dogs during the first year of life predict the outcome in a later temperament test. Appl Anim Behav Sci. 2014; 155:93–100.
Article
15. Foyer P, Svedberg AM, Nilsson E, Wilsson E, Faresjö Å, Jensen P. Behavior and cortisol responses of dogs evaluated in a standardized temperament test for military working dogs. J Vet Behav. 2016; 11:7–12.
Article
16. Groppetti D, Pecile A, Palestrini C, Marelli SP, Boracchi P. A national census of birth weight in purebred dogs in Italy. Animals (Basel). 2017; 7:pii: E43.
Article
17. Hill JR, Winger QA, Long CR, Looney CR, Thompson JA, Westhusin ME. Development rates of male bovine nuclear transfer embryos derived from adult and fetal cells. Biol Reprod. 2000; 62:1135–1140.
Article
18. Hong SG, Jang G, Kim MK, Oh HJ, Park JE, Kang JT, Koo OJ, Kim DY, Lee BC. Dogs cloned from fetal fibroblasts by nuclear transfer. Anim Reprod Sci. 2009; 115:334–339.
Article
19. Horvath G, Andersson H, Paulsson G. Characteristic odour in the blood reveals ovarian carcinoma. BMC Cancer. 2010; 10:643.
Article
20. Horváth Z, Igyártó BZ, Magyar A, Miklósi Á. Three different coping styles in police dogs exposed to a short-term challenge. Horm Behav. 2007; 52:621–630.
Article
21. Hvozdík A, Kottferová J, Alberto J, Ondrašovič M. Test of social dominance in dogs. Veterinarski Arhiv. 2003; 73:237–246.
22. Issel-Tarver L, Rine J. The evolution of mammalian olfactory receptor genes. Genetics. 1997; 145:185–195.
Article
23. Jang G, Hong SG, Kang JT, Park JE, Oh HJ, Park CK, Ha JH, Kim DY, Kim MK, Lee BC. Conservation of the Sapsaree (Canis familiaris), a Korean Natural Monument, using somatic cell nuclear transfer. J Vet Med Sci. 2009; 71:1217–1220.
Article
24. Jang G, Hong SG, Oh HJ, Kim MK, Park JE, Kim HJ, Kim DY, Lee BC. A cloned toy poodle produced from somatic cells derived from an aged female dog. Theriogenology. 2008; 69:556–563.
Article
25. Jang G, Kim MK, Oh HJ, Hossein MS, Fibrianto YH, Hong SG, Park JE, Kim JJ, Kim HJ, Kang SK, Kim DY, Lee BC. Birth of viable female dogs produced by somatic cell nuclear transfer. Theriogenology. 2007; 67:941–947.
Article
26. Jeffery N. Neurological examination of dogs 1. Techniques. In Practice. 2001; 23:118–130.
Article
27. Jones AC, Gosling SD. Temperament and personality in dogs (Canis familiaris): a review and evaluation of past research. Appl Anim Behav Sci. 2005; 95:1–53.
Article
28. Kim GA, Oh HJ, Kim MJ, Jo YK, Choi J, Kim JW, Lee TH, Lee BC. Effect of primary culture medium type for culture of canine fibroblasts on production of cloned dogs. Theriogenology. 2015; 84:524–530.
Article
29. Kim MJ, Kang SC, Kim JH, Oh HJ, Kim GA, Jo YK, Choi J, Kim H, Lee YH, Yoo JM, Eom KD, Lee BC. Ectopic liver and gallbladder in a cloned dog: possible nonheritable anomaly. Theriogenology. 2015; 84:995–1002.
Article
30. Kim MJ, Oh HJ, Kim GA, Jo YK, Choi J, Kim HJ, Choi HY, Kim HW, Choi MC, Lee BC. Reduced birth weight, cleft palate and preputial abnormalities in a cloned dog. Acta Vet Scand. 2014; 56:18.
Article
31. Kim MJ, Oh HJ, Kim GA, Setyawan EMN, Choi YB, Lee SH, Petersen-Jones SM, Ko CJ, Lee BC. Birth of clones of the world’s first cloned dog. Sci Rep. 2017; 7:15235.
Article
32. Kim MJ, Oh HJ, Kim GA, Suh HN, Jo YK, Choi YB, Kim DH, Han HJ, Lee BC. Altering histone acetylation status in donor cells with suberoylanilide hydroxamic acid does not affect dog cloning efficiency. Theriogenology. 2015; 84:1256–1261.
Article
33. Kim MJ, Oh HJ, Park JE, Kim GA, Park EJ, Jang G, Lee BC. Effects of mineral supplements on ovulation and maturation of dog oocytes. Theriogenology. 2012; 78:110–115.
Article
34. Kim MJ, Oh HJ, Park JE, Kim GA, Park EJ, Jo YK, Lee BC. Duration of gestation in pregnant dogs carrying cloned fetuses. Theriogenology. 2013; 79:257–260.
Article
35. Kim MJ, Park JE, Oh HJ, Hong SG, Kang JT, Rhim SH, Lee DW, Ra JC, Lee BC. Preservation through cloning of superior canine scent detection ability for cancer screening. J Vet Clin. 2015; 32:352–355.
Article
36. Lee BC, Kim MK, Jang G, Oh HJ, Yuda F, Kim HJ, Hossein MS, Kim JJ, Kang SK, Schatten G, Hwang WS. Dogs cloned from adult somatic cells. Nature. 2005; 436:641.
Article
37. Lee JB, Park C. Seoul National University Investigation Committee. Molecular genetics: verification that Snuppy is a clone. Nature. 2006; 440:E2–E3.
38. Maejima M, Inoue-Murayama M, Tonosaki K, Matsuura N, Kato S, Saito Y, Weiss A, Murayama Y, Ito SI. Traits and genotypes may predict the successful training of drug detection dogs. Appl Anim Behav Sci. 2007; 107:287–298.
Article
39. Mazzone PJ. Analysis of volatile organic compounds in the exhaled breath for the diagnosis of lung cancer. J Thorac Oncol. 2008; 3:774–780.
Article
40. McCulloch M, Jezierski T, Broffman M, Hubbard A, Turner K, Janecki T. Diagnostic accuracy of canine scent detection in early-and late-stage lung and breast cancers. Integr Cancer Ther. 2006; 5:30–39.
Article
41. Miller G, Zhu G, Wright MJ, Hansell NK, Martin NG. The heritability and genetic correlates of mobile phone use: a twin study of consumer behavior. Twin Res Hum Genet. 2012; 15:97–106.
Article
42. Oh HJ, Choi J, Kim MJ, Kim GA, Jo YK, Choi YB, Lee BC. Propagation of elite rescue dogs by somatic cell nuclear transfer. Anim Sci J. 2016; 87:21–26.
Article
43. Oh HJ, Hong SG, Park JE, Kang JT, Kim MJ, Kim MK, Kang SK, Kim DY, Jang G, Lee BC. Improved efficiency of canine nucleus transfer using roscovitine-treated canine fibroblasts. Theriogenology. 2009; 72:461–470.
Article
44. Olson PN, Hall MF, Peterson JK, Johnson GS. Using genetic technologies for promoting canine health and temperament. Anim Reprod Sci. 2004; 82-83:225–230.
Article
45. Park JE, Kim MK, Kang JT, Oh HJ, Hong SG, Kim DY, Jang G, Lee BC. Growth and hematologic characteristics of cloned dogs derived from adult somatic cell nuclear transfer. Cell Reprogram. 2010; 12:141–150.
Article
46. Park JE, Oh HJ, Hong SG, Kim MJ, Kim GA, Koo OJ, Kang SK, Jang G, Lee BC. Effective donor cell fusion conditions for production of cloned dogs by somatic cell nuclear transfer. Theriogenology. 2011; 75:777–782.
Article
47. Robbins PJ, Ramos MT, Zanghi BM, Otto CM. Environmental and physiological factors associated with stamina in dogs exercising in high ambient temperatures. Front Vet Sci. 2017; 4:144.
Article
48. Saetre P, Strandberg E, Sundgren PE, Pettersson U, Jazin E, Bergström TF. The genetic contribution to canine personality. Genes Brain Behav. 2006; 5:240–248.
Article
49. Schnieke AE, Kind AJ, Ritchie WA, Mycock K, Scott AR, Ritchie M, Wilmut I, Colman A, Campbell KH. Human factor IX transgenic sheep produced by transfer of nuclei from transfected fetal fibroblasts. Science. 1997; 278:2130–2133.
Article
50. Scott JP, Fuller JL. Genetics and the social behavior of the dog. Chicago: University of Chicago Press;2012.
51. Shin CW, Kim GA, Park WJ, Park KY, Jeon JM, Oh HJ, Kim MJ, Lee BC. Learning, memory and exploratory similarities in genetically identical cloned dogs. J Vet Sci. 2016; 17:563–567.
Article
52. Sonoda H, Kohnoe S, Yamazato T, Satoh Y, Morizono G, Shikata K, Morita M, Watanabe A, Morita M, Kakeji Y, Inoue F, Maehara Y. Colorectal cancer screening with odour material by canine scent detection. Gut. 2011; 60:814–819.
Article
53. van Soelen IL, Brouwer RM, van Leeuwen M, Kahn RS, Hulshoff Pol HE, Boomsma DI. Heritability of verbal and performance intelligence in a pediatric longitudinal sample. Twin Res Hum Genet. 2011; 14:119–128.
Article
54. Volhard J, Volhard W. Dog training for dummies. New York: John Wiley & Sons;2010.
55. Walker DB, Walker JC, Cavnar PJ, Taylor JL, Pickel DH, Hall SB, Suarez JC. Naturalistic quantification of canine olfactory sensitivity. Appl Anim Behav Sci. 2006; 97:241–254.
Article
56. Walker JC, Hall SB, Walker DB, Kendal-Reed MS, Hood AF, Niu XF. Human odor detectability: new methodology used to determine threshold and variation. Chem Senses. 2003; 28:817–826.
Article
57. Williams H, Pembroke A. Sniffer dogs in the melanoma clinic? Lancet. 1989; 1:734.
Article
58. Willis CM, Church SM, Guest CM, Cook WA, McCarthy N, Bransbury AJ, Church MR, Church JC. Olfactory detection of human bladder cancer by dogs: proof of principle study. BMJ. 2004; 329:712.
Article
59. Wilmut I, Schnieke AE, McWhir J, Kind AJ, Campbell KH. Viable offspring derived from fetal and adult mammalian cells. Nature. 1997; 385:810–813.
Article
60. Yeo JH, Kim JH, Kim SY, Lee SJ, Park NW, Oh HJ, Kim MJ, Kim GA, Jo YK, Lee BC, Eom K. Echocardiographic evaluation of cardiovascular function in cloned dogs. J Vet Clin. 2015; 32:301–307.
Article
61. Young LE, Sinclair KD, Wilmut I. Large offspring syndrome in cattle and sheep. Rev Reprod. 1998; 3:155–163.
Article
Full Text Links
  • JVS
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr