Ann Dermatol.  2018 Oct;30(5):602-605. 10.5021/ad.2018.30.5.602.

Collision Tumor Associated with Sarcomatoid Eccrine Porocarcinoma and Basal Cell Carcinoma

• An HJ
• Seol JE
• Yun JY
• Kang MS

• KMID: 2419753
• DOI: http://doi.org/10.5021/ad.2018.30.5.602

Abstract

A "˜collision' tumor refers to the existence of two different neoplasms within the same tumor. Sometimes, the term "˜biphasic tumor' is also used. However, a "˜collision' tumor is defined as the occurrence of two neoplasms within proximity of each other yet maintaining distinctly defined, separate boundaries. In contrast, a "˜biphasic' tumor demonstrates two or more phenotypically distinct neoplastic cell populations merging within the same space. Here, we report a case of collision tumor associated with sarcomatoid eccrine porocarcinoma and basal cell carcinoma arising in a 57-year-old male patient.

Keyword

Basal cell carcinoma; Eccrine porocarcinoma

MeSH Terms

Carcinoma, Basal Cell*
Eccrine Porocarcinoma*
Humans
Male
Middle Aged

Figure

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  Fig. 1 Large protruding ulcerated beefy red nodule with adjacent pinhead to bean-sized multiple nevi are present in the right zygoma (A). A flat, ill-defined, rice grain-sized, eroded, dark brown-colored patch in the superior portion of nasal bridge, between the eyes (B).

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  Fig. 2 A relatively well circumscribed, hypercellular tumor occupying the dermis downward to the subcutaneous fat layer, with surface ulceration (A: H&E, ×10). Glandular architecture (arrow) is mixed with haphazardly arranged spindle cells (B: H&E, ×100) showing moderate nuclear pleomorphism with numerous mitoses (C: H&E, ×400). Nests of basaloid cells with peripheral nuclear palisading in the upper dermis (D: H&E, ×40).

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  Fig. 3 Poorly differentiated tumor cells diffusely express cytokeratin (A), p63 (B) and vimentin (C). Carcinoembryonic antigen (D) and epithelial membrane antigen (E) is positive in gland forming cells, which are negative for vimentin. Ductal cells highlighted by special stain, periodic acid-Schiff (PAS)/diastase-resistant PAS (F) (A~F: H&E, ×400).

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