Clin Endosc.  2018 Jul;51(4):352-356. 10.5946/ce.2017.117.

Closing the Gaps: Endoscopic Suturing for Large Submucosal and Full-Thickness Defects

• Kukreja K
• Chennubhotla S
• Bhandari B
• Arora A
• Singhal S

• KMID: 2419706
• DOI: http://doi.org/10.5946/ce.2017.117

Abstract

This article is a systematic review of relevant literature on endoscopic suturing as a primary closure technique for large submucosal and full-thickness defects after endoscopic mucosal resection (EMR), endoscopic submucosal dissection (ESD), and endoscopic full-thickness resection (EFTR). A comprehensive literature search was conducted through 2016 by using PubMed, to find peer-reviewed original articles. The specific factors considered were the procedural indications and details, success rates, clinical outcomes including complications, and study limitations. Six original articles were included in the final review: two with non-human subjects and four with human subjects. The mean success rate of endoscopic suturing was 97.4% (100% for human subjects and 95.4% for non-human subjects). The procedural time ranged from 7 to 89 min. The average size and depth of lesions were 2.71 cm (3.74 cm [human] and 1.96 cm [non-human]) and 1.52 cm, respectively. The technique itself had no reported impact on mortality. In conclusion, endoscopic suturing is a minimally invasive technique for the primary closure of defects caused by EMR, ESD, and EFTR, with a high success and low complication rate.

Keyword

Endoscopic suturing; Endoscopic mucosal resection; Endoscopic submucosal dissection; Submucosal defects; Endoscopic full-thickness defects

MeSH Terms

Humans
Mortality

Figure

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  Fig. 1. (A) Overstitch Endcap with Helix. (B) Overstitch device on dual channel endoscope. Used with permission from Apollo Endosurgery, Austin, TX, USA.

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  Fig. 2. (A) Large defect following endoscopic submucosal dissection. (B) Following closure of defect with Overstitch device.

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