World J Mens Health.  2018 Sep;36(3):248-254. 10.5534/wjmh.170003.

Is It Worth Treating Non-Bothering Nocturia? Results of a Multicenter Prospective Observational Study

Affiliations
  • 1Department of Urology, Chonnam National University Medical School, Gwangju, Korea.
  • 2Department of Urology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.
  • 3Department of Urology, School of Medicine, The Catholic University of Korea, Seoul, Korea.
  • 4Department of Urology, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
  • 5Department of Urology, Chonbuk National University Medical School, Jeonju, Korea.
  • 6Department of Urology, Pusan National University School of Medicine, Busan, Korea.
  • 7Department of Urology, Yeungnam University College of Medicine, Daegu, Korea.
  • 8Department of Urology, Korea University College of Medicine, Seoul, Korea.
  • 9Department of Urology, Inje University Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.
  • 10Department of Urology, SMG-SNU Boramae Medical Center, Seoul, Korea.
  • 11Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • 12Department of Urology, Gyeongsang National University School of Medicine, Jinju, Korea.
  • 13Department of Urology, Konkuk University Chungju Hospital, Konkuk University School of Medicine, Chungju, Korea. yskurol@kku.ac.kr

Abstract

PURPOSE
The purpose of this study was to evaluate the efficacy of treatment in patients with non-bothering nocturia.
MATERIALS AND METHODS
In this prospective multicenter study, patients who visited hospitals for treatment of voiding symptoms were enrolled. Inclusion criteria were: 1) men >45 years, and 2) nocturia ≥2 confirmed by a three-day voiding diary. Subjects were divided into non-bothering and bothering groups based on International Consultation on Incontinence Questionnaire Nocturia (ICIQ-N) question 2b. Changes in voiding symptoms, frequency of nocturia, and bothersomeness were evaluated with international prostate symptom score (IPSS), ICIQ-N, and three-day voiding diary at 4 and 12 weeks after treatment.
RESULTS
A total of 48 patients in the non-bothering nocturia group and 50 patients in the bothering nocturia group who completed the 12-week treatment were analyzed. The total IPSS was decreased by 5.8 in the non-bothering group and 5.2 in the bothering group. There was no significant difference in decrease of IPSS between the two groups. Both groups showed significant reduction in discomfort of nocturia. The ICIQ-N 2b score decreased from 3.9 to 2.7 (p=0.01) in the non-bothering group and from 6.9 to 4.6 (p=0.02) in the bothering group. The number of nocturia episodes was significantly decreased in both groups.
CONCLUSIONS
Regardless of discomfort associated with nocturia, both groups showed significant improvement in nocturia-related discomfort and voiding symptoms. These results suggest that patients with nocturia who were unaware of its discomfort benefited from treatment.

Keyword

Lower urinary tract symptoms; Nocturia; Prostatic hyperplasia; Therapeutics

MeSH Terms

Humans
Lower Urinary Tract Symptoms
Male
Nocturia*
Observational Study*
Prospective Studies*
Prostate
Prostatic Hyperplasia

Figure

  • Fig. 1 The schematic showing study protocol. F/U: follow-up.

  • Fig. 2 Change of variables after 12-week treatment. (A) The change of total international prostate symptom score (IPSS). (B) The change of International Consultation on Incontinence Questionnaire Nocturia (ICIQ-N) 2b visual analogue scale. (C) The change of nocturia episode.


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