Ann Dermatol.  2018 Jun;30(3):351-355. 10.5021/ad.2018.30.3.351.

Pancreatic Extraskeletal Osteosarcoma Metastasizing to the Scalp

• Kim YJ
• Kim HT
• Won CH
• Chang SE
• Lee MW
• Choi JH
• Lee WJ

• KMID: 2419180
• DOI: http://doi.org/10.5021/ad.2018.30.3.351

Abstract

Extraskeletal osteosarcoma (ESOS) is a rare mesenchymal soft-tissue neoplasm that accounts for approximately 1% of all soft-tissue sarcomas. Over 70% of these malignant tumor progress to local recurrence and metastasis. It commonly metastasizes to the lungs, lymph nodes, bone, and skin and has a poor survival outcome. Cutaneous metastasis is exceedingly rare and known to be a sign of widespread metastases. We present a 57-year-old woman who presented with a rapidly growing protuberant mass on the scalp that was finally diagnosed as metastatic ESOS from a primary pancreatic ESOS. To our knowledge, there has been no reported case of pancreatic ESOS metastasizing to the scalp.

Keyword

Neoplasm metastasis; Pancreas; Sarcoma; Scalp; Skin

MeSH Terms

Female
Humans
Lung
Lymph Nodes
Middle Aged
Neoplasm Metastasis
Osteosarcoma*
Pancreas
Recurrence
Sarcoma
Scalp*
Skin

Figure

• 

  Fig. 1 A solitary, 18×20 mm-sized, firm, erythematous, round tender nodule on the scalp.

• 

  Fig. 2 (A) A tumor mass showing a solitary, sharply demarcated pancreatic mass (H&E, ×40). (B) Slightly spindled and epithelioid atypical tumor cells with pleomorphic nuclei and multiple mitoses (H&E, ×100). (C, D) Positive reactivity for high-molecular-weight (C) CD99 and (D) vimentin (C, D: ×200).

• 

  Fig. 3 (A) A subcutaneous tumor mass showing atypical spindle-cell proliferation (H&E, ×40). (B) Pleomorphic and hyperchromatic tumor cells with a prominent osteoid component and osteoclast-like giant cells (H&E, ×100). (C, D) Positive reactivity for high-molecular-weight (C) CD99 and (D) vimentin (C, D: ×200).

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