Korean J Orthod.  2018 May;48(3):163-171. 10.4041/kjod.2018.48.3.163.

Antibacterial and remineralization effects of orthodontic bonding agents containing bioactive glass

  • 1Department of Orthodontics, Dental Research Institute, Pusan National University Dental Hospital, Yangsan, Korea. kimyongil@pusan.ac.kr
  • 2R&D Center, Upex·med Co., Ltd., Anyang, Korea.
  • 3School of Materials Science and Engineering, Pusan National University, Busan, Korea.
  • 4Department of Oral Microbiology, School of Dentistry, Pusan National University, Yangsan, Korea.
  • 5Institute of Translational Dental Sciences, School of Dentistry, Pusan National University, Yangsan, Korea.
  • 6Department of Dental Materials, Pusan National University, Yangsan, Korea. y0k0916@pusan.ac.kr


The aim of this study was to evaluate the mechanical and biological properties of orthodontic bonding agents containing silver- or zinc-doped bioactive glass (BAG) and determine the antibacterial and remineralization effects of these agents.
BAG was synthesized using the alkali-mediated solgel method. Orthodontic bonding agents containing BAG were prepared by mixing BAG with flowable resin. Transbondâ„¢ XT (TXT) and Charmfilâ„¢ Flow (CF) were used as controls. Ion release, cytotoxicity, antibacterial properties, the shear bond strength, and the adhesive remnant index were evaluated. To assess the remineralization properties of BAG, micro-computed tomography was performed after pH cycling.
The BAG-containing bonding agents showed no noticeable cytotoxicity and suppressed bacterial growth. When these bonding agents were used, demineralization after pH cycling began approximately 200 to 300 µm away from the bracket. On the other hand, when CF and TXT were used, all surfaces that were not covered by the adhesive were demineralized after pH cycling.
Our findings suggest that orthodontic bonding agents containing silver- or zinc-doped BAG have stronger antibacterial and remineralization effects compared with conventional orthodontic adhesives; thus, they are suitable for use in orthodontic practice.


Bioactive glass; Adhesive; Antibacterial; Remineralization
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