Korean J Ophthalmol.  2018 Aug;32(4):290-295. 10.3341/kjo.2017.0139.

Choroidal Thickness Indicates Subclinical Ocular and Systemic Inflammation in Eyes with Behçet Disease without Active Inflammation

Affiliations
  • 1Department of Ophthalmology, Ajou University School of Medicine, Suwon, Korea. kie114@hanmail.net
  • 2Kong Eye Hospital, Seoul, Korea.
  • 3Department of Ophthalmology, Pocheon Hospital, Gyeonggi Provincial Medical Center, Pocheon, Korea.
  • 4Department of Dermatology, Ajou University School of Medicine, Suwon, Korea.

Abstract

PURPOSE
To investigate whether subfoveal choroidal thickness, measured using enhanced depth imaging optical coherence tomography (EDI-OCT), is an indicator of subclinical ocular or systemic inflammation in eyes with Behçet disease (BD) without active ocular inflammation.
METHODS
A retrospective analysis was used to examine clinical features of non-uveitic patients with BD (NUBD group), patients with a previous history of Behçet uveitis in an inactive state (IUBD group), and healthy controls were evaluated from October 2014 to September 2015. Subfoveal choroidal thickness was measured using EDI-OCT.
RESULTS
The NUBD group included 46 eyes in 24 patients; the IUBD group included 16 eyes in 11 patients; and the control group included 35 eyes in 23 individuals. The mean subfoveal choroidal thicknesses differed significantly among these groups. Choroidal thickness was significantly greater in the NUBD (310.5 ± 81.0 µm) than in the IUBD (263.1 ± 56.6 µm, p = 0.013) and control (256.9 ± 67.9 µm, p = 0.002) groups. The disease activity score was significantly higher in the NUBD than in the IUBD group (p < 0.001), while the use of cyclosporine was significantly associated with choroidal thickness in eyes with NUBD (p = 0.039).
CONCLUSIONS
Subfoveal choroidal thickness, as measured by EDI-OCT, may be a clinical indicator of subclinical ocular inflammation and systemic inflammation in BD patients without active ocular inflammation.

Keyword

Behcet syndrome; Choroidal thickness; Inflammation

MeSH Terms

Behcet Syndrome*
Choroid*
Cyclosporine
Humans
Inflammation*
Retrospective Studies
Tomography, Optical Coherence
Uveitis
Cyclosporine

Figure

  • Fig. 1 Subfoveal choroidal thicknesses in the three groups of eyes. Mean choroidal thickness was significantly greater in the non-uveitic Behçet disease (NUBD) than in the inactive uveitic Behçet disease (IUBD) and control groups.


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