J Pathol Transl Med.  2018 Jul;52(4):248-251. 10.4132/jptm.2017.10.23.

Sudden Child Death due to Thrombotic Giant Coronary Artery Aneurysms Complicated by Atypical Kawasaki Disease: An Autopsy Case

Affiliations
  • 1Shinhyunho Pathology Clinic, Daegu, Korea.
  • 2Department of Pathology, Kyungpook National University Hospital, Daegu, Korea.
  • 3Department of Forensic Medicine, School of Medicine, Kyungpook National University, Daegu, Korea. sanghan1@knu.ac.kr

Abstract

No abstract available.


MeSH Terms

Aneurysm*
Autopsy*
Child*
Coronary Vessels*
Humans
Mucocutaneous Lymph Node Syndrome*

Figure

  • Fig. 1. Coronary artery aneurysms. The left main coronary artery (LCA), left anterior descending coronary artery (LAD), and right coronary artery (RCA) form giant aneurysms. Luminal thrombi were removed during examination. AO, aorta; LA appendage, left atrium appendage; PT, pulmonary trunk; RA, right atrium; SVC, superior vena cava.

  • Fig. 2. Myocardial infarction of ventricular wall. (A) Posterior wall of left ventricle shows coagulative necrosis along with wavy fibers (arrow). Widened spaces between the dead myofibers contain edema fluid and scattered neutrophils. (B) Posterior wall of right ventricle reveals granulation tissue characterized by loose collagen and capillaries. Patchy fibrosis is observed, with compensatory hypertrophic changes in adjacent myocytes.

  • Fig. 3. Elastin stain. The right coronary artery shows destruction of internal elastic lamina and inflammatory cell infiltration.


Reference

1. Kato H, Sugimura T, Akagi T, et al. Long-term consequences of Kawasaki disease: a 10- to 21-year follow-up study of 594 patients. Circulation. 1996; 94:1379–85.
2. Singh S, Agarwal S, Bhattad S, et al. Kawasaki disease in infants below 6 months: a clinical conundrum? Int J Rheum Dis. 2016; 19:924–8.
Article
3. Choi YS, Kwon T, Lee H, Lee SY, Lee WT. Medicolegal investigation of Kawasaki disease: three cases of sudden death by coronary artery lesions. Korean J Leg Med. 2003; 27:39–44.
4. Manlhiot C, Yeung RS, Clarizia NA, Chahal N, McCrindle BW. Kawasaki disease at the extremes of the age spectrum. Pediatrics. 2009; 124:e410–5.
Article
5. Pucci A, Martino S, Tibaldi M, Bartoloni G. Incomplete and atypical Kawasaki disease: a clinicopathologic paradox at high risk of sudden and unexpected infant death. Pediatr Cardiol. 2012; 33:802–5.
Article
6. Diana MC, Villa G, Gattorno M, et al. Sudden death in an infant revealing atypical Kawasaki disease. Pediatr Emerg Care. 2006; 22:35–7.
Article
7. Tsuda E, Tsujii N, Kimura K, Suzuki A. Distribution of Kawasaki disease coronary artery aneurysms and the relationship to coronary artery diameter. Pediatr Cardiol. 2017; 38:932–40.
Article
8. McCrindle BW, Rowley AH, Newburger JW, et al. Diagnosis, treatment, and long-term management of Kawasaki disease: a scientific statement for health professionals from the American Heart Association. Circulation. 2017; 135:e927–99.
Article
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