J Vet Sci.  2018 Jul;19(4):577-581. 10.4142/jvs.2018.19.4.577.

Isolation and characterization of Korean porcine deltacoronavirus strain KNU16-07

Affiliations
  • 1Animal Virology Laboratory, School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, Kyungpook National University, Daegu 41566, Korea. changhee@knu.ac.kr
  • 2Animal Disease Diagnostic Division, Animal and Plant Quarantine Agency, Gimcheon 39660, Korea. naturelkk@korea.kr
  • 3College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Korea.
  • 4College of Veterinary Medicine, Jeju National University, Jeju 63243, Korea.

Abstract

Porcine deltacoronavirus (PDCoV) has emerged in several pig-raising countries and has been a causative pathogen associated with diarrheal diseases in South Korea since 2014. In the present study, we were able to isolate and cultivate a Korean PDCoV strain (KNU16-07) in cell culture and investigate its pathogenicity. PDCoV-inoculated piglets showed watery diarrhea accompanied by acute enteritis in the natural host. Sequencing analysis demonstrated the genetic stability of KNU16-07 for at least thirty serial passages.

Keyword

cell culture isolation; genome analysis; porcine deltacoronavirus; virulence
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