J Audiol Otol.
2018 Apr;22(2):105-109. 10.7874/jao.2017.00150.
Clinical Safety and Efficacy of Autologous Bone Marrow-Derived Mesenchymal Stem Cell Transplantation in Sensorineural Hearing Loss Patients
- Affiliations
-
- 1Department of Otorhinolaryngology-Head and Neck Surgery, The Catholic University of Korea College of Medicine, Seoul, Korea. khpent@catholic.ac.kr
- 2Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Korea.
- KMID: 2415950
- DOI: http://doi.org/10.7874/jao.2017.00150
Abstract
- Stem cell transplantation represents a promising therapy for several degenerating and necrotic diseases. In several animal studies, we could find hearing restoration after inoculation of the mesenchymal stem cells' as well as mesenchymal stem cells' differentiation of hair cells and spiral ganglion. But until now, no clinical study has been reported directly for the human being. In this pilot studies, we applied mesenchymal stem cells to human beings trans-venously. Although we verified the safety of the autologous bone marrow stem cell transplantation in sensorineural hearing loss patients but we could not achieve significant improvement in hearing.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Therapeutic Efficacy of Bone Marrow Derived Mesenchymal Stem Cells in Ototoxic Sensorineural Hearing Loss
- Neural Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells: Applicability for Inner Ear Therapy
- The Evolving Role of Myeloablative Chemotherapy with Stem Cell Transplantation for the Treatment of Autoimmune Disease
- Role of Endogenous Bone Marrow Stem Cells Mobilization in Repair of Damaged Inner Ear in Rats
- Stem Cell Research in Cardiovascular System
