J Korean Diabetes.  2018 Jun;19(2):76-81. 10.4093/jkd.2018.19.2.76.

Environmental Pollution and Diabetes

Affiliations
  • 1Department of Endocrinology and Metabolism, Chosun University Hospital, Gwangju, Korea. endocrine@chosun.ac.kr

Abstract

Endocrine disrupting chemicals (EDCs) are exogenous chemicals contained in industrial substances and plasticizers commonly utilized worldwide. Human exposure to such chemicals, particularly at low-doses, is omnipresent, persistent, and occurs in complex mixtures. EDCs include bisphenol A, phthalates, pesticides, and persistent organic pollutants such as polychlorinated biphenyls. Burgeoning epidemiological, animal, and cellular data link environmental EDCs to metabolic dysfunction. In the last three decades, the number of diabetic patients has drastically increased worldwide, with current statistics suggesting that the number will double in the next two decades. There is epidemiological and experimental evidence linking background exposure to a selection of environmental EDCs with diabetes and impaired glucose metabolism. EDC may be related to increased risk of diabetes.

Keyword

Diabetes; Endocrine disruptors; Environmental pollution

MeSH Terms

Animals
Complex Mixtures
Endocrine Disruptors
Environmental Pollution*
Glucose
Humans
Metabolism
Pesticides
Plasticizers
Plastics
Polychlorinated Biphenyls
Complex Mixtures
Endocrine Disruptors
Glucose
Pesticides
Plasticizers
Plastics
Polychlorinated Biphenyls

Reference

1. International Diabetes Federation. Diabetes atlas. 6th ed. Brussels: International Diabetes Federation;2013.
2. Gore AC, Chappell VA, Fenton SE, Flaws JA, Nadal A, Prins GS, Toppari J, Zoeller RT. Executive Summary to EDC-2: the Endocrine Society's second Scientific Statement on endocrine-disrupting chemicals. Endocr Rev. 2015; 36:593–602.
Article
3. Ruiz D, Becerra M, Jagai JS, Ard K, Sargis RM. Disparities in environmental exposures to endocrine-disrupting chemicals and diabetes risk in vulnerable populations. Diabetes Care. 2018; 41:193–205.
Article
4. Kouznetsova M, Huang X, Ma J, Lessner L, Carpenter DO. Increased rate of hospitalization for diabetes and residential proximity of hazardous waste sites. Environ Health Perspect. 2007; 115:75–79.
Article
5. Vasiliu O, Cameron L, Gardiner J, Deguire P, Karmaus W. Polybrominated biphenyls, polychlorinated biphenyls, body weight, and incidence of adult-onset diabetes mellitus. Epidemiology. 2006; 17:352–359.
Article
6. Wu H, Bertrand KA, Choi AL, Hu FB, Laden F, Grandjean P, Sun Q. Persistent organic pollutants and type 2 diabetes: a prospective analysis in the nurses' health study and meta-analysis. Environ Health Perspect. 2013; 121:153–161.
Article
7. Turyk M, Anderson H, Knobeloch L, Imm P, Persky V. Organochlorine exposure and incidence of diabetes in a cohort of Great Lakes sport fish consumers. Environ Health Perspect. 2009; 117:1076–1082.
Article
8. Van Larebeke N, Sioen I, Hond ED, Nelen V, Van de Mieroop E, Nawrot T, Bruckers L, Schoeters G, Baeyens W. Internal exposure to organochlorine pollutants and cadmium and self-reported health status: a prospective study. Int J Hyg Environ Health. 2015; 218:232–245.
Article
9. Song Y, Chou EL, Baecker A, You NC, Song Y, Sun Q, Liu S. Endocrine-disrupting chemicals, risk of type 2 diabetes, and diabetes-related metabolic traits: a systematic review and meta-analysis. J Diabetes. 2016; 8:516–532.
Article
10. Ranjit N, Siefert K, Padmanabhan V. Bisphenol-A and disparities in birth outcomes: a review and directions for future research. J Perinatol. 2010; 30:2–9.
Article
11. Vandenberg LN, Hunt PA, Myers JP, Vom Saal FS. Human exposures to bisphenol A: mismatches between data and assumptions. Rev Environ Health. 2013; 28:37–58.
Article
12. von Goetz N, Wormuth M, Scheringer M, Hungerbühler K. Bisphenol A: how the most relevant exposure sources contribute to total consumer exposure. Risk Anal. 2010; 30:473–487.
Article
13. Sun Q, Cornelis MC, Townsend MK, Tobias DK, Eliassen AH, Franke AA, Hauser R, Hu FB. Association of urinary concentrations of bisphenol A and phthalate metabolites with risk of type 2 diabetes: a prospective investigation in the Nurses' Health Study (NHS) and NHSII cohorts. Environ Health Perspect. 2014; 122:616–623.
Article
14. Hu J, Yang S, Wang Y, Goswami R, Peng C, Gao R, Zhou H, Zhang Y, Cheng Q, Zhen Q, Li Q. Serum bisphenol A and progression of type 2 diabetic nephropathy: a 6-year prospective study. Acta Diabetol. 2015; 52:1135–1141.
Article
15. Serrano SE, Braun J, Trasande L, Dills R, Sathyanarayana S. Phthalates and diet: a review of the food monitoring and epidemiology data. Environ Health. 2014; 13:43.
Article
16. Ait Bamai Y, Araki A, Kawai T, Tsuboi T, Saito I, Yoshioka E, Kanazawa A, Tajima S, Shi C, Tamakoshi A, Kishi R. Associations of phthalate concentrations in floor dust and multi-surface dust with the interior materials in Japanese dwellings. Sci Total Environ. 2014; 468-469:147–157.
Article
17. Watkins DJ, Peterson KE, Ferguson KK, Mercado-García A, Tamayo y Ortiz M, Cantoral A, Meeker JD, Téllez-Rojo MM. Relating phthalate and BPA exposure to metabolism in peripubescence: the role of exposure timing, sex, and puberty. J Clin Endocrinol Metab. 2016; 101:79–88.
Article
18. Smith D. Worldwide trends in DDT levels in human breast milk. Int J Epidemiol. 1999; 28:179–188.
Article
19. Lee DH, Steffes MW, Sjödin A, Jones RS, Needham LL, Jacobs DR Jr. Low dose of some persistent organic pollutants predicts type 2 diabetes: a nested case-control study. Environ Health Perspect. 2010; 118:1235–1242.
Article
20. Lee DH, Lind PM, Jacobs DR Jr, Salihovic S, van Bavel B, Lind L. Polychlorinated biphenyls and organochlorine pesticides in plasma predict development of type 2 diabetes in the elderly: the prospective investigation of the vasculature in Uppsala Seniors (PIVUS) study. Diabetes Care. 2011; 34:1778–1784.
Article
21. Starling AP, Umbach DM, Kamel F, Long S, Sandler DP, Hoppin JA. Pesticide use and incident diabetes among wives of farmers in the Agricultural Health Study. Occup Environ Med. 2014; 71:629–635.
Article
22. Shaikh S, Jagai JS, Ashley C, Zhou S, Sargis RM. Underutilized and under threat: environmental policy as a tool to address diabetes risk. Curr Diab Rep. 2018; 18:25.
Article
23. Brook RD, Xu X, Bard RL, Dvonch JT, Morishita M, Kaciroti N, Sun Q, Harkema J, Rajagopalan S. Reduced metabolic insulin sensitivity following sub-acute exposures to low levels of ambient fine particulate matter air pollution. Sci Total Environ. 2013; 448:66–71.
Article
24. Brook RD, Sun Z, Brook JR, Zhao X, Ruan Y, Yan J, Mukherjee B, Rao X, Duan F, Sun L, Liang R, Lian H, Zhang S, Fang Q, Gu D, Sun Q, Fan Z, Rajagopalan S. Extreme air pollution conditions adversely affect blood pressure and insulin resistance: the air pollution and cardiometabolic disease study. Hypertension. 2016; 67:77–85.
Article
25. Thiering E, Cyrys J, Kratzsch J, Meisinger C, Hoffmann B, Berdel D, von Berg A, Koletzko S, Bauer CP, Heinrich J. Long-term exposure to traffic-related air pollution and insulin resistance in children: results from the GINIplus and LISAplus birth cohorts. Diabetologia. 2013; 56:1696–1704.
Article
26. Weinmayr G, Hennig F, Fuks K, Nonnemacher M, Jakobs H, Möhlenkamp S, Erbel R, Jöckel KH, Hoffmann B, Moebus S. Heinz Nixdorf Recall Investigator Group. Long-term exposure to fine particulate matter and incidence of type 2 diabetes mellitus in a cohort study: effects of total and traffic-specific air pollution. Environ Health. 2015; 14:53.
Article
27. O'Donnell MJ, Fang J, Mittleman MA, Kapral MK, Wellenius GA. Fine particulate air pollution (PM2.5) and the risk of acute ischemic stroke. Epidemiology. 2011; 22:422–431.
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