Investig Clin Urol.  2018 Jul;59(4):246-251. 10.4111/icu.2018.59.4.246.

Intravesical electrical stimulation treatment for overactive bladder: An observational study

• Yune JJ
• Shen JK
• Pierce MA
• Hardesty J
• Kim J
• Siddighi S

• KMID: 2414757
• DOI: http://doi.org/10.4111/icu.2018.59.4.246

Abstract

PURPOSE
Intravesical electrical stimulation treatment (IVES) has been successfully used to treat neurogenic bladder. We report the results of an observational study regarding the use of IVES for women with overactive bladder syndrome (OAB) and/or urgency urinary incontinence (UUI).
MATERIALS AND METHODS
IVES was performed in women with OAB (defined by frequency ≥8/day, nocturia ≥2/night, or ≥3 episodes of UUI on 3-day voiding diary) who failed prior medical therapy. Subjects underwent 4 weeks of treatment with an 8-Fr Detruset™ IVES catheter. Primary outcome was Patient Global Impression of Improvement (PGI-I) at 3 months. Secondary outcomes included Visual Analog Scale (VAS), Short Form OAB Questionnaire (OAB-q SF), Pelvic Floor Distress Inventory (PFDI), Pelvic Floor Impact Questionnaire (PFIQ), reduction in frequency and UUI on voiding diary, and adverse effects. Analysis was done with paired t-tests and Wilcoxon signed rank tests.
RESULTS
Seventeen subjects completed the study. At 4 weeks post-treatment, 15 improved on PGI-I (11 subjects: "˜a little better', 2: "˜much better', 2: "˜very much better'). There were significant improvements in symptom bother and health-related quality of life as measured by OAB-q SF and pelvic organ prolapse and urinary distress as measured by PFDI. Frequency decreased from 10.3±4.3 at baseline to 8.9±2.3 (p=0.04) at 3 months. No pain was reported during treatment. There was one urinary tract infection during the study period. No other adverse events were reported.
CONCLUSIONS
IVES appears to be a safe and effective novel treatment for OAB. Larger comparative studies are needed to investigate its potential for long-term treatment.

Keyword

Electrical stimulation; Urinary bladder, overactive; Urinary incontinence, urge

MeSH Terms

Catheters
Electric Stimulation*
Female
Humans
Nocturia
Observational Study*
Pelvic Floor
Pelvic Organ Prolapse
Quality of Life
Urinary Bladder, Neurogenic
Urinary Bladder, Overactive*
Urinary Incontinence
Urinary Incontinence, Urge
Urinary Tract Infections
Visual Analog Scale

Figure

• 

  Fig. 1 Patient global impression of improvement scales (PGI-I) at 2, 3, 4, and 12 weeks after first treatment. a:Time from the first treatment. b:Equals to 8 weeks from the end of 4 weeks treatment.

• 

  Fig. 2 Overactive bladder symptom bother and health related quality of life outcomes at baseline and at 2, 3, 4, and 12 weeks after treatment. OAB-q SF, Overactive Bladder Questionnaire Short Form.

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  Fig. 3 Pelvic organ prolapse distress inventory-6 (POPDI-6), urogenital distress inventory-6 (UDI-6), and colorectal anal distress inventory-8 (CRAD-8) outcomes at baseline and at 2, 3, 4, and 12 weeks after treatment.

• 

  Fig. 4 Pelvic Floor Impact Questionnaire (PFIQ)-7 at baseline and at 2, 3, 4, and 12 weeks after treatment.

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