Ann Dermatol.  2018 Apr;30(2):218-221. 10.5021/ad.2018.30.2.218.

Pagetoid Bowen Disease Initially Misdiagnosed as Ectopic Extramammary Paget's Disease

• Lee J
• Kim M
• Moon J
• Yoon HS
• Cho S
• Park HS

• KMID: 2414685
• DOI: http://doi.org/10.5021/ad.2018.30.2.218

Abstract

Pagetoid Bowen disease is a histological variant of Bowen disease which demonstrates large pale staining cells (pagetoid cells). It requires differential diagnosis from other cutaneous malignancies with similar patterns, such as extramammary Paget's disease (EMPD) and Pagetoid melanoma in situ. Herein, we report a case of Pagetoid Bowen disease which was initially misdiagnosed as ectopic EMPD.

Keyword

Bowen's disease; Immunohistochemistry; Pagetoid Bowen's disease; Pagetoid cells

MeSH Terms

Bowen's Disease*
Diagnosis, Differential
Immunohistochemistry
Melanoma
Paget Disease, Extramammary*

Figure

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  Fig. 1 (A) Dark brown to erythematous scaly plaque on left lower leg. (B) Paget cells with abundant pale cytoplasm and large pleomorphic nuclei are widely distributed in the epidermis (H&E, ×400).

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  Fig. 2 (A~G) Immunohistochemistry. Neoplastic cells are negative for cytokeratin 7 (CK7) (A), CK20 (C), carcinoembryonic antigen (D), and diffusely positive for epithelial membrane antigen (B). The neoplastic cells show diffuse positivity for p63 (E), CK5/6 (F). Negative S-100 immunohistochemical staining (A~G: ×100).

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