J Bone Metab.  2018 May;25(2):99-106. 10.11005/jbm.2018.25.2.99.

Is Sarcopenia a Potential Risk Factor for Distal Radius Fracture? Analysis Using Propensity Score Matching

• Lee JK
• Yoon BH
• Oh CH
• Kim JG
• Han SH

• KMID: 2413371
• DOI: http://doi.org/10.11005/jbm.2018.25.2.99

Abstract

BACKGROUND
Cases of low-energy-induced distal radius fracture (DRF) are increasing. Sarcopenia is considered to be an independent risk factor for fragility fractures. We compared body appendicular lean muscle mass (ALM) and bone mineral density (BMD) in patients with DRF and a comparable control population. This study aimed to investigate the correlation between skeletal muscle mass and DRF.
METHODS
We performed a retrospective review of patients diagnosed with fragility DRF. The DRF group included 87 patients treated at our institute. The control group comprised data for 87 individuals in the general population from among 2,124 selected using nearest-neighbor propensity scoring, based on age, weight, height, and body mass index. All medical conditions and past history were also compared between the two groups.
RESULTS
The relative overall ALM, combining arm and leg lean body mass divided by height squared, was not significantly different (DRF group, 6.093 kg/m²; controls, 5.945 kg/m²). T-score, a parameter of BMD, was significantly different between groups (DRF, −2.42; controls, −2.05). The proportion of patients with osteoporosis was significantly different (DRF, 44 [50.6%] vs. control, 29 [33.3%], respectively).
CONCLUSIONS
Patients with DRF did not have significantly lower average lean body mass. BMD was significantly lower in patients with DRF than in controls.

Keyword

Osteoporosis; Osteoporotic fractures; Radius fractures; Risk factors; Sarcopenia

MeSH Terms

Arm
Body Mass Index
Bone Density
Humans
Leg
Muscle, Skeletal
Osteoporosis
Osteoporotic Fractures
Propensity Score*
Radius Fractures*
Radius*
Retrospective Studies
Risk Factors*
Sarcopenia*

Figure

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  Fig. 1 Flow sheet of patient selection process for the distal radius fracture (DRF) and control groups.

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  Fig. 2 Statistics of nearest neighbor propensity score matching, age, height, weight, and body mass index (BMI). (A) Distribution of propensity scores. (B) Change of absolute standardized differences.

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  Fig. 3 Comparison of bone mineral density (BMD), with significant difference (P=0.028). DRF, distal radius fracture.

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  Fig. 4 Comparison of appendicular skeletal mass (ASM) divided by height squared, without significance (P=0.189). Ht, height; DRF, distal radius fracture.

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