J Korean Acad Nurs.  2016 Jun;46(3):420-430. 10.4040/jkan.2016.46.3.420.

Effect of Cancer Symptoms and Fatigue on Chemotherapy-related Cognitive Impairment and Depression in People with Gastrointestinal Cancer

• Oh PJ
• Lee JR

• KMID: 2413348
• DOI: http://doi.org/10.4040/jkan.2016.46.3.420

Abstract

PURPOSE
The purpose of this study was to test a hypothetical model of chemotherapy-related cognitive impairment (CRCI) and depression in people with gastrointestinal cancer.
METHODS
A purposive sample of 198 patients undergoing chemotherapy was recruited from November 2014 to July 2015. The instruments were Everyday Cognition (ECog), Hospital Anxiety Depression Scale (HADS), Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F), and M. D. Anderson Symptom Inventory-Gastrointestinal Cancer Module. Data were analyzed using descriptive statistics, correlation, and path analysis.
RESULTS
CRCI was directly affected by cancer symptoms (β=.19, p=.004) and fatigue (β=.56, p<.001)(R²=47.2%). Depression was directly affected by fatigue (β=.48, p<.001) and CRCI (β=.27, p<.001). However, The impact of cancer symptoms on depression was confirmed through the mediating effect of CRCI.
CONCLUSION
Results indicate that in patients with gastrointestinal cancer undergoing chemotherapy along with the direct physiologic effects (fatigue, symptoms) of cancer treatment may have altered cognitive function leading to depression.

Keyword

Mild cognitive impairment; Neoplasm; Fatigue; Depression

MeSH Terms

Adult
Aged
Anemia/etiology
Antineoplastic Agents/*adverse effects/therapeutic use
Anxiety
Camptothecin/adverse effects/analogs & derivatives/therapeutic use
Cognitive Dysfunction/*etiology
Depression/*etiology
Drug Therapy, Combination
*Fatigue
Female
Fluorouracil/adverse effects/therapeutic use
Gastrointestinal Neoplasms/drug therapy/*pathology
Hemoglobins/metabolism
Humans
Male
Memory
Middle Aged
Organoplatinum Compounds/adverse effects/therapeutic use
Paclitaxel/adverse effects/therapeutic use
Surveys and Questionnaires
Translating
Antineoplastic Agents
Hemoglobins
Organoplatinum Compounds
Paclitaxel
Fluorouracil
Camptothecin

Figure

• 

  Figure 1-A Path diagram of the hypothetical model.

• 

  Figure 1-B Modified path diagram of the study.

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