J Pathol Transl Med.  2018 May;52(3):202-205. 10.4132/jptm.2017.09.05.

Aberrant CD3 Expression in a Relapsed Plasma Cell Neoplasm

• Go JH

• KMID: 2412935
• DOI: http://doi.org/10.4132/jptm.2017.09.05

Abstract

No abstract available.

MeSH Terms

Neoplasms, Plasma Cell*
Plasma Cells*
Plasma*

Figure

• 

  Fig. 1. Magnetic resonance imaging (MRI) showed pathologic fracture of 12th thoracic vertebral body with anterior epidural and both paravertebral extensions at initial presentation (A, arrow). Follow-up MRI at 4 months after initial diagnosis revealed multiple nodular masses in posterior paravertebral muscle, both gluteal muscles, and both iliac bones (B, arrows).

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  Fig. 2. In initial bone biopsy, the tumor was composed of differentiated plasma cells (A), which were positive for CD138 (B), but negative for CD3 (C). (D) The tumor cells were positive for Epstein-Barr virus-encoded RNA (EBER) in situ hybridization. (E) In relapsed soft tissue biopsy, the tumor was composed of medium-sized blastic cells admixed with smaller plasmacytic cells. Most of the tumor cells were strongly positive for CD138 (F) and CD3 (G). (H) The tumor cells were also positive for EBER ISH.

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