Ann Hepatobiliary Pancreat Surg.  2018 May;22(2):164-168. 10.14701/ahbps.2018.22.2.164.

Multidisciplinary approach for treatment of primary hepatic choriocarcinoma in adult male patient

• Ahn Y
• Kim JH
• Park CS
• Kim TE
• Hwang S
• Lee SG

• KMID: 2412433
• DOI: http://doi.org/10.14701/ahbps.2018.22.2.164

Abstract

Choriocarcinoma is a rare malignant germ cell tumor and it usually occurs in the gonads (ovary or testis) and uterus. Primary hepatic choriocarcinoma (PHC) is a variant of choriocarcinoma featuring sole liver presentation without any evidence of gonodal involvements. Adult male patients with PHC carry dismal prognosis and their median survival period was less than 5 months. We herein present a first Korean case of a 54-year-old male patient with adult PHC, who was treated by surgical resection and chemotherapy through a multidisciplinary approach.

Keyword

Liver; Choriocarcinoma; Surgery; Chemotherapy

MeSH Terms

Adult*
Choriocarcinoma*
Drug Therapy
Female
Gonads
Humans
Liver
Male*
Middle Aged
Neoplasms, Germ Cell and Embryonal
Pregnancy
Prognosis
Uterus

Figure

• 

  Fig. 1 Pre- and postoperative computed tomography (CT) scan findings. Preoperative CT scan showed that the initial tumor diameter was 6.3 cm (A). The size of the main tumor increased to 11 cm after 3 weeks (B), and new nodules (arrow) were found on the right and left lobes in the same CT scan (C and D); CT scan taken 1 week after surgery showed increase in the sizes of the remnant tumors (arrows) to up to 2.5 cm (E and F); Follow-up CT after chemotherapy showed a decrease in the size of the remnant multiple tumors (arrows) to achieve partial response by RECIST (G and H).

• 

  Fig. 2 Pathological findings. Gross appearance showed the multilobulated hemorrhagic mass with extracapsular mass extension (arrows) (A); Biphasic pleomorphic cells of cytotrophoblasts and syncytiotrophoblasts (arrow), and hemorrhage and necrosis (arrowhead) were observed (H&E stain, ×200) (B); Diffuse expression of β-hCG was identified in immunohistochemistry staining (×200) (C).

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