Clin Psychopharmacol Neurosci.  2018 May;16(2):224-227. 10.9758/cpn.2018.16.2.224.

Donepezil for Compulsive Behavior in Degenerative Dementia: Case Series

Affiliations
  • 1Department of Psychiatry, All India Institute of medical Sciences, Bhuvaneshwar, India.
  • 2Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India. vs8sreeraj@yahoo.com
  • 3Department of Pharmacology, All India Institute of medical Sciences, Bhuvaneshwar, India.

Abstract

Diagnosing and managing dementia, presenting with compulsions is challenging. Presented are three cases, a possible representative subset of the Donepezil responders. Selective degeneration of dorsolateral prefrontal cortex networking striatum leading to compulsions would be amenable to cholinergic modulation.

Keyword

Repetition compulisons; Psychosis; Dementia; Major neurocognitive disorder; Donepezil
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