Gut Liver.  2017 May;11(3):401-408. 10.5009/gnl16079.

Magnetic Resonance Elastography and Diffusion Weighted Imaging in the Evaluation of Hepatic Fibrosis in Chronic Hepatitis B

Affiliations
  • 1Department of Diagnostic Imaging, National University of Singapore, Singapore.
  • 2Department of Biomedical Engineering, University of Calgary, Calgary, Canada.
  • 3Department of Radiology, King Fahd Hospital of the University, Dammam University College of Medicine, Al Khobar, Saudi Arabia.
  • 4South West Radiology, Liverpool, Australia.
  • 5Department of Gastroenterology and Hepatology, National University of Singapore, Singapore.
  • 6Department of Pathology, National University of Singapore, Singapore.
  • 7Department of Radiology, Mayo Clinic, Rochester, MN, USA. venkatesh.sudhakar@mayo.edu

Abstract

BACKGROUND/AIMS
Comparison of the accuracy of magnetic resonance elastography (MRE) and diffusion weighted imaging (DWI) for the diagnosis of liver fibrosis in patients with chronic hepatitis B (CHB).
METHODS
In this retrospective analysis, we investigated 63 patients with CHB and liver fibrosis. DWI was performed with both breath-hold (DWI-BH) and free-breathing (DWI-FB) sequences (b=0, 500). The mean liver stiffness and apparent diffusion coefficient (ADC) were calculated by drawing regions of interest maps. Fibrosis staging according to the METAVIR system was independently performed by an experienced pathologist. A receiver operating curve (ROC) analysis was conducted to determine the accuracy of MRE, DWI-BH and DWI-FB in the detection and stratification of liver fibrosis. The performance of the detection of significant fibrosis (≥F2), advanced fibrosis (≥F3), and cirrhosis (F4) was also evaluated by comparing areas under the ROC.
RESULTS
There was a moderate and significantly negative correlation between the ADC values and liver stiffness. The accuracies for the detection of ≥F2/≥F3/F4 stage fibrosis with DWI-FB, DWI-BH and MRE were 0.84/0.76/0.72, 0.72/0.83/0.79 and 0.99/0.99/0.98, respectively. The performance of MRE was significantly better than DWI-FB and DWI-BH. There were no significant differences between the performance of DWI-FB and DWI-BH.
CONCLUSIONS
MRE is more accurate than DWI for the detection and stratification of liver fibrosis in CHB.

Keyword

Elastography; Liver cirrhosis; Diffusion weighted imaging; Accuracy; Cirrhosis
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