Gut Liver.  2016 May;10(3):356-361. 10.5009/gnl14483.

The Effects of Helicobacter pylori Eradication Therapy for Chronic Idiopathic Thrombocytopenic Purpura

Affiliations
  • 1Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea. dhljohn@yahoo.co.kr

Abstract

BACKGROUND/AIMS
The aim of this study was to evaluate the ability of Helicobacter pylori eradication treatment to increase platelet counts in Korean patients with chronic idiopathic thrombocytopenic purpura (ITP).
METHODS
A total of 102 patients were evaluated against two criteria. First, those diagnosed with H. pylori infections in whom eradication was successful were assigned to the H. pylori-positive and -eradicated group (n=39), whereas those diagnosed with H. pylori infections in whom eradication failed were assigned to the H. pylori-positive and -non-eradicated group (n=3), and those without H. pylori infections were assigned to the H. pylori-negative group (n=60). Second, patients with complete remission in whom the platelet recovery effect was maintained over the average follow-up period of 6 months after eradication therapy were defined as the responder group (n=58), whereas those with partial or no response were defined as the nonresponder group (n=44).
RESULTS
The platelet counts of the H. pylori-positive and -eradicated group were significantly increased 6 months after eradication therapy compared to those of the H. pylori-positive and -non-eradicated group and the H. pylori-negative group (43.2±29.1 to 155.3±68.7×10(3)/μL vs 42.5±28.1 to 79.8±59.7×10(3)/μL vs 43.1±28.9 to 81.2±62.2×10(3)/μL; p=0.041). The eradication therapy success rate in the responder group was 100.0% (39/39), in contrast to the nonresponder group (0%, 0/3) (p<0.001).
CONCLUSIONS
H. pylori eradication therapy was related to increased platelet count, and successful eradication affected the increased platelet count in Korean patients with chronic ITP.

Keyword

Helicobacter pylori; Eradication therapy; Purpura, thrombocytopenic, idiopathic; Platelet count

MeSH Terms

Antiviral Agents/therapeutic use
Chronic Disease
*Disease Eradication
Female
Helicobacter Infections/ethnology/*prevention & control
*Helicobacter pylori
Humans
Male
Middle Aged
Platelet Count
Purpura, Thrombocytopenic, Idiopathic/*complications/ethnology
Republic of Korea/ethnology
Retrospective Studies
Treatment Outcome
Antiviral Agents
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