Tissue Eng Regen Med.  2018 Apr;15(2):211-222. 10.1007/s13770-017-0103-9.

Effects of Hexachlorophene, a Chemical Accumulating in Adipose Tissue, on Mouse and Human Mesenchymal Stem Cells

Affiliations
  • 1Departament of Regenerative Medicine and Cell Biology, Military Institute of Hygiene and Epidemiology, Kozielska 4 Street, 01163 Warsaw, Poland. rztox@yahoo.com
  • 2Department of Microwave Safety, Military Institute of Hygiene and Epidemiology, Kozielska 4 Street, 01163 Warsaw, Poland.
  • 3CNRS, UMR 6290, Institute of Genetics and Development of Rennes, Cell Cycle Group, 35043 Rennes, France.
  • 4UEB, UMS CNRS 3480, Faculty of Medicine, University Rennes 1, 35043 Rennes, France.
  • 5The Houston Methodist Research Institute, 6670 Bertner Ave, Houston, TX 77030, USA.
  • 6Department of Surgery, The Houston Methodist Hospital, 6565 Fannin Street, Houston, TX 77030, USA.
  • 7MD Anderson Cancer Center, Department of Genetics, The University of Texas, 1515 Holcombe Blvd, Houston, TX 77030, USA.

Abstract

The hexachlorophene (HCP) is a highly lipophilic chlorinated bisphenol present in hygienic and dermatological products. The HCP accumulates preferentially in adipose tissue that is a privileged source of mesenchymal stem cells (MSCs). The evaluation of the potential effects of HCP on MSCs is important for their medical application. Here we examined the effects of HCP on murine adipose tissue-derived stem cells (ADSCs) and human umbilical cord-derived stem cells (UCSCs) in cell culture. We found that 10−4 and 10−5 M HCP inhibits proliferation, osteogenesis and increases apoptosis of ADSCs and UCSCs. While the effect of HCP on proliferation and differentiation potential of these two cell lines was similar, the UCSCs appeared much more resistant to HCP-induced apoptosis than ADSCs. These results suggest that the adipose tissue-derived ADSCs have higher sensitive for HCP than umbilical cord-derived UCSCs and indicate that the umbilical cord can be a preferable source of MSCs for prospective medical applications in the future.

Keyword

Hexachlorophene; Mesenchymal stem cells; Adipose tissue; Unbilical cord; Apoptosis

MeSH Terms

Adipose Tissue*
Animals
Apoptosis
Cell Culture Techniques
Cell Line
Hexachlorophene*
Humans*
Mesenchymal Stromal Cells*
Mice*
Osteogenesis
Prospective Studies
Stem Cells
Umbilical Cord
Hexachlorophene
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