Ann Pediatr Endocrinol Metab.  2018 Mar;23(1):33-37. 10.6065/apem.2018.23.1.33.

Prevalence of autoimmune thyroiditis in patients with type 1 diabetes: a long-term follow-up study

• Hwang GB
• Yoon JS
• Park KJ
• Lee HS
• Hwang JS

• KMID: 2409788
• DOI: http://doi.org/10.6065/apem.2018.23.1.33

Abstract

PURPOSE
Type 1 diabetes mellitus (DM) is associated with autoimmune diseases such as thyroiditis. Therefore, we aimed to investigate the prevalence of autoimmune thyroiditis in patients with type 1 DM.
METHODS
A total of 102 patients who were diagnosed and followed up (mean age, 8.1±4.0 years) in Ajou University Hospital were enrolled in this study. All the patients were evaluated for beta cell autoimmunity, including insulin autoantibody, glutamic acid decarboxylase antibodies (GADA), and islet cell antibody. Moreover, autoantibodies to thyroid peroxidase and thyroglobulin were assessed at initial diagnosis and annually thereafter.
RESULTS
The mean patient age (49 men and 53 women) was 19.2±4.8 years. The prevalence of at least one thyroid antibody was 30.4%. Patients with thyroid anti­bodies had a significantly higher frequency of GADA at the time of the diagnosis. Autoimmune thyroiditis was more prevalent in the older age group. GADA was a significant risk factor for development of thyroid autoantibodies after diagnosis of type 1 DM (odds ratio, 4.45; 95% confidence interval, 1.399-14.153).
CONCLUSIONS
In patients with type 1 DM, the prevalence of autoimmune thyroiditis was higher than in the general population. Moreover, GADA positivity at diagnosis was associated with thyroid autoimmunity.

Keyword

Autoimmune thyroiditis; Type 1 diabetes; Thyroid autoantibody

MeSH Terms

Antibodies
Autoantibodies
Autoimmune Diseases
Autoimmunity
Diabetes Mellitus, Type 1
Diagnosis
Follow-Up Studies*
Glutamate Decarboxylase
Humans
Insulin
Iodide Peroxidase
Islets of Langerhans
Male
Prevalence*
Risk Factors
Thyroglobulin
Thyroid Gland
Thyroiditis
Thyroiditis, Autoimmune*
Antibodies
Autoantibodies
Glutamate Decarboxylase
Insulin
Iodide Peroxidase
Thyroglobulin

Figure

• 

  Fig. 1. Frequency of thyroid autoantibodies positivity in children with type 1 mellitus according to current age.

Reference

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