Nat Prod Sci.
2015 Mar;21(1):25-29. 10.0000/nps.2015.21.1.25.
Isolation and Structure Determination of an Imidazo-pyrimidine, 5-Chlorocavernicolin, Maleimide oximes and Nucleosides from a Marine Sponge Extract
- Affiliations
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- 1College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea. mkna@cnu.ac.kr
- 2Department of Bio and Fermentation Convergence Technology, Kookmin University, Seoul 136-702, Korea.
- KMID: 2409595
- DOI: http://doi.org/10.0000/nps.2015.21.1.25
Abstract
- In a continuation of our studies to discover bioactive secondary metabolites from marine sources, we further investigated samples from a tryptamine and phenyl-alkane producing sponge, which resulted in the isolation of four uncommon small molecules and five nucleosides. Their structures were determined to be 7,8-dihydroimidazo[1,5-c]pyrimidin-5(6H)-one (1), 5-chlorocavernicolin (2), maleimide-5-oxime (3), 3-methylmaleimide-5-oxime (4), uridine (5), 2'-deoxyuridine (6), thymidine (7), adenine (8), and adenosine (9) by spectroscopic analyses. The isolated compounds were evaluated for inhibitory activity against soluble epoxide hydrolase (sEH) as well as the Wnt/beta-catenine signaling pathway.
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