Perinatology.  2018 Mar;29(1):13-19. 10.14734/PN.2018.29.1.13.

Late and Insufficient Phosphorus Supplementation is Associated with Early Severe Hypophosphatemia in Extremely Low Birth Weight Infants with Early Amino Acid Administration

• Yang SM
• Noh OK
• Lee JH
• Park MS

• KMID: 2409107
• DOI: http://doi.org/10.14734/PN.2018.29.1.13

Abstract

OBJECTIVE
To investigate the incidence of early severe hypophosphatemia, and examine the associated clinical factors and outcomes, in extremely low birth weight infants (ELBWI) who received early amino acid administration.
METHODS
Medical records of 82 ELBWI were retrospectively reviewed. Severe hypophosphatemia was defined as a serum phosphate level < 2 mg/dL during the first week after birth.
RESULTS
Nineteen ELBWI (23.2%) experienced severe hypophosphatemia. The supplementation of phosphorus was started significantly later in the hypophosphatemia group compared to that in the control group (P=0.036). Small for gestational age infants (SGAI) (P=0.006) and bronchopulmonary dysplasia (P=0.016) were more prevalent in the hypophosphatemia group compared to that in the control group.
CONCLUSION
Early severe hypophosphatemia is common in ELBWI. Late and insufficient supplementation of phosphorus and SGAI were associated with severe hypophosphatemia.

Keyword

Infant; Extremely low birth weight; Hypophosphatemia; Bronchopulmonary dysplasia

MeSH Terms

Bronchopulmonary Dysplasia
Gestational Age
Humans
Hypophosphatemia*
Incidence
Infant*
Infant, Low Birth Weight*
Infant, Newborn
Medical Records
Parturition
Phosphorus*
Retrospective Studies
Phosphorus