J Korean Soc Transplant.  2018 Mar;32(1):1-6. 10.4285/jkstn.2018.32.1.1.

The Role of B Cells in Transplantation Rejection

• Kim TJ

• KMID: 2408661
• DOI: http://doi.org/10.4285/jkstn.2018.32.1.1

Abstract

B cells play a role in graft rejection via several mechanisms. Specifically, B cells produce high-affinity antibodies to alloantigens including allogeneic major histocompatibility complex (MHC) with the help of follicular helper T cells. B cells also function as antigen-presenting cells for alloreactive T cells, resulting in the activation of alloreactive T cells. Conversely, the frequency of regulatory B cells increases under inflammatory conditions and suppresses the rejection process. Here, the differential roles of the major B cell subpopulations (B-1, follicular B, marginal zone B, and regulatory B cells) involved in transplantation rejection are discussed together with their interaction with T cells.

Keyword

B cell; Transplant rejection; Antibody diversity; Helper T cell; B-1 cell

MeSH Terms

Antibodies
Antibody Diversity
Antigen-Presenting Cells
B-Lymphocytes*
B-Lymphocytes, Regulatory
Graft Rejection*
Isoantigens
Major Histocompatibility Complex
T-Lymphocytes
T-Lymphocytes, Helper-Inducer
Antibodies
Isoantigens