Ann Rehabil Med.  2014 Apr;38(2):269-272.

Central Hyperthermia Treated With Baclofen for Patient With Pontine Hemorrhage

• Lee HC
• Kim JM
• Lim JK
• Jo YS
• Kim SK

Abstract

Central hyperthermia is a very rare disease; however, once it happens, it is associated with a poor prognosis and high mortality for patients with severe brainstem strokes. Following a pontine hemorrhage, a 46-years-old female developed prolonged hyperthermia. Work-ups to the fever gave no significant clues for the origin of fever, and hyperthermia did not respond to any empirical antibiotics or antipyretic agents. The patient's body temperature still fluctuated in a range of 37.5degrees C to 39.2degrees C. Considering the lesion of hemorrhage, we suspected central hyperthermia rather than infectious diseases. We started with baclofen administration at a dose of 30 mg/day. The body temperature changed to a range of 36.6degrees C to 38.2degrees C. We raised the dose of baclofen to 60 mg/day. The patient's body temperature finally dropped to a normal range. Central hyperthermia, caused by failures of thermoregulatory pathways in brainstem, following the pontine hemorrhage rarely occurs. Baclofen can be used to treat suspected central hyperthermia in a patient with pontine hemorrhage.

Keyword

Fever; Pons; Hemorrhage; Baclofen

MeSH Terms

Anti-Bacterial Agents
Antipyretics
Baclofen*
Body Temperature
Brain Stem
Communicable Diseases
Female
Fever*
Hemorrhage*
Humans
Mortality
Pons
Prognosis
Rare Diseases
Reference Values
Stroke
Anti-Bacterial Agents
Antipyretics
Baclofen

Figure

• 

  Fig. 1 Computed tomography demonstrated hemorrhage in brainstem and middle cerebellar peduncle which are mainly posterior pons and the largest diameter is 29 mm.

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  Fig. 2 Fever patterns of prolonged central hyperthermia in a pontine hemorrhage.

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