Nutr Res Pract.  2018 Apr;12(2):160-165. 10.4162/nrp.2018.12.2.160.

Associations of serum levels of vitamins A, C, and E with the risk of cognitive impairment among elderly Koreans

Affiliations
  • 1Department of Clinical Nutrition, School of Public Health, Dongduk Women's University, Seoul 02748, Korea.
  • 2Department of Foods and Nutrition, College of Natural Sciences, Dongduk Women's University, 60, Hwarang-ro 13-gil, Seongbuk-gu, Seoul 02748, Korea. yjyang@dongduk.ac.kr
  • 3Department of Preventive Medicine, Hanyang University, Seoul 04763, Korea.
  • 4Department of Psychiatry, Hanyang University College of Medicine, Seoul 04763, Korea.
  • 5Statistics and Data Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul 06351, Korea.

Abstract

BACKGROUND/OBJECTIVES
Korea is quickly becoming an aged society. Dementia is also becoming a vital public health problem in Korea. Cognitive impairment as a pre-stage of dementia shares most risk factors for dementia. The aim of the present study was to determine associations of serum levels of vitamins A, C, and E with the risk of cognitive impairment among elderly Koreans.
SUBJECTS/METHODS
In this cross-sectional study, a total of 230 participants aged 60-79 years from Yangpyeong cohort were included. Cognitive function was assessed by the Korean version of the Mini-Mental State Examination for Dementia Screening. The logistic multivariable regression model was applied to determine the effect of serum vitamins A, C, and E on the risk of cognitive impairment.
RESULTS
There was no significant association between the risk of cognitive impairment and serum levels of vitamin A and vitamin C. There was a significant odd ratio when the second tertile group of beta-gamma tocopherol level was compared to the first tertile group [odds ratio (OR) = 0.37, 95% confidence interval (CI) = 0.14-0.98, P for trend = 0.051]. In subgroup analyses, there were significant negative associations between beta-gamma tocopherol level and the risk of cognitive impairment in men (OR = 0.17, 95% CI = 0.03-0.87, P for trend = 0.028), non-drinkers or former drinkers (OR = 0.13, 95% CI = 0.02-0.66, P for trend = 0.025), and non-smokers or former smokers (OR = 0.27, 95% CI = 0.09-0.82, P for trend = 0.017).
CONCLUSION
Serum beta-gamma tocopherol levels tended to be inversely associated with the risk of cognitive impairment. Further prospective large-scaled studies are needed to examine this association.

Keyword

Dementia; cognition; vitamin A; ascorbic acid; vitamin E

MeSH Terms

Aged*
Ascorbic Acid
Cognition
Cognition Disorders*
Cohort Studies
Cross-Sectional Studies
Dementia
Humans
Korea
Male
Mass Screening
Prospective Studies
Public Health
Risk Factors
Tocopherols
Vitamin A
Vitamin E
Vitamins*
Ascorbic Acid
Tocopherols
Vitamin A
Vitamin E
Vitamins

Cited by  2 articles

Serum 25-hydroxyvitamin D and cognitive function in Korean older adults living in rural area
Ye Som Shin, Bo Youl Choi, Mi Kyung Kim, Yoon Jung Yang
J Nutr Health. 2019;52(5):465-474.    doi: 10.4163/jnh.2019.52.5.465.

Serum 25-hydroxyvitamin D and cognitive function in Korean older adults living in rural area
Ye Som Shin, Bo Youl Choi, Mi Kyung Kim, Yoon Jung Yang
J Nutr Health. 2019;52(5):465-474.    doi: 10.4163/jnh.2019.52.5.465.


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