Clin Exp Otorhinolaryngol.  2018 Mar;11(1):65-70. 10.21053/ceo.2017.00374.

Is Ginger Effective in Reducing Post-tonsillectomy Morbidity? A Prospective Randomised Clinical Trial

Affiliations
  • 1Department of Otolaryngology, Koç University Hospital, Istanbul, Turkey. ikocak@kuh.ku.edu.tr
  • 2Department of Otolaryngology, Darıca Farabi State Hospital, Kocaeli, Turkey.

Abstract


OBJECTIVES
An assessment of the effects of ginger on pain, nausea, vomiting, bleeding, and wound site healing that occur after tonsillectomy.
METHODS
This prospective clinical study was participated by 49 patients aged 18-45 years out of 56 patients that underwent tonsillectomy and regularly attended follow-up visits. The patients were randomly divided into two groups. Group 1 consisted of 23 patients that used ginger capsules and group 2 consisted of 26 patients that did not use ginger capsules in addition to the routine antibiotic and paracetamol treatment following tonsillectomy. The pain, nausea, vomiting, and bleeding scores of patients were assessed on days 1, 4, 7, and 10 by using the visual analogue scale. Similarly, the epithelialization degrees of tonsillar bed were assessed on postoperative days 1, 4, 7, and 10 and regular oral intake times of patients were recorded.
RESULTS
There were no differences between groups in terms of age and sex. On the postoperative days 1, 4, 7, and 10, the pain scores were lower in the group 1 (all P < 0.001) and there were no differences between the two groups in terms of postoperative nausea, vomiting, and bleeding scores (P=0.35 and P=0.53). On the postoperative days 7 and 10, epithelialization in the tonsil bed was quicker in the group 1 (P=0.041 and P=0.026) and the regular oral intake time was earlier in group 1 (P < 0.001).
CONCLUSION
In this study, ginger relieved pain, accelerated wound site epithelialization, and decreased duration of oral intake following tonsillectomy. It did not result in postoperative bleeding or any other complications. Ginger can be recommended as an adjunct to routine medical treatment for decreasing morbidity following tonsillectomy.

Keyword

Ginger; Tonsillectomy; Pain; Wound Healing

MeSH Terms

Acetaminophen
Capsules
Clinical Study
Follow-Up Studies
Ginger*
Hemorrhage
Humans
Nausea
Palatine Tonsil
Postoperative Nausea and Vomiting
Prospective Studies*
Tonsillectomy
Vomiting
Wound Healing
Wounds and Injuries
Acetaminophen
Capsules

Figure

  • Fig. 1. Comparison of pain visual analog scale scores on postoperative (postop) days 1, 4, 7, and 10. Vertical error bars represent standard error. ***P<0.001.

  • Fig. 2. Representative view of tonsillar bed at postoperative day 10. (A) Patient who took ginger, (group 1), (B) patient who did not take ginger (group 2).


Reference

1. Hanci D, Altun H. Effectiveness of hyaluronic acid in post-tonsillectomy pain relief and wound healing: a prospective, double-blind, controlled clinical study. Int J Pediatr Otorhinolaryngol. 2015; Sep. 79(9):1388–92.
2. Tugrul S, Degirmenci N, Eren SB, Dogan R, Veyseller B, Ozturan O. Analgesic effect of magnesium in post-tonsillectomy patients: a prospective randomized clinical trial. Eur Arch Otorhinolaryngol. 2015; Sep. 272(9):2483–7.
3. Fukuda K. Intravenous opioid anesthetics. In : Miller RD, editor. Miller’s anesthesia. Kidlington (UK): Churchill Livingstone Elsevier;2005. p. 379–437.
4. Ozlugedik S, Genc S, Unal A, Elhan AH, Tezer M, Titiz A. Can postoperative pains following tonsillectomy be relieved by honey? A prospective, randomized, placebo controlled preliminary study. Int J Pediatr Otorhinolaryngol. 2006; Nov. 70(11):1929–34.
5. Siupsinskiene N, Zekoniene J, Padervinskis E, Zekonis G, Vaitkus S. Efficacy of sucralfate for the treatment of post-tonsillectomy symptoms. Eur Arch Otorhinolaryngol. 2015; Feb. 272(2):271–8.
Article
6. Kara M, Erdogan H, Altinisik HB, Aylanc H, Guclu O, Derekoy FS. Does topical use of autologous serum help to reduce post-tonsillectomy morbidity? A prospective, controlled preliminary study. J Laryngol Otol. 2016; Jul. 130(7):662–8.
Article
7. Ali BH, Blunden G, Tanira MO, Nemmar A. Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): a review of recent research. Food Chem Toxicol. 2008; Feb. 46(2):409–20.
Article
8. Kiuchi F, Iwakami S, Shibuya M, Hanaoka F, Sankawa U. Inhibition of prostaglandin and leukotriene biosynthesis by gingerols and diarylheptanoids. Chem Pharm Bull (Tokyo). 1992; Feb. 40(2):387–91.
Article
9. Ribel-Madsen S, Bartels EM, Stockmarr A, Borgwardt A, Cornett C, Danneskiold-Samsoe B, et al. A synoviocyte model for osteoarthritis and rheumatoid arthritis: response to ibuprofen, betamethasone, and ginger extract. A cross-sectional in vitro study. Arthritis. 2012; 2012:505842. https://doi.org/10.1155/2012/505842.
Article
10. Bakht MA, Alajmi MF, Alam P, Alam A, Alam P, Aljarba TM. Theoretical and experimental study on lipophilicity and wound healing activity of ginger compounds. Asian Pac J Trop Biomed. 2014; Apr. 4(4):329–33.
Article
11. Bhagavathula N, Warner RL, DaSilva M, McClintock SD, Barron A, Aslam MN, et al. A combination of curcumin and ginger extract improves abrasion wound healing in corticosteroid-impaired hairless rat skin. Wound Repair Regen. 2009; May-Jun. 17(3):360–6.
Article
12. Montazeri AS, Hamidzadeh A, Raei M, Mohammadiun M, Montazeri AS, Mirshahi R, et al. Evaluation of oral ginger efficacy against postoperative nausea and vomiting: a randomized, double- blinded clinical trial. Iran Red Crescent Med J. 2013; Dec. 15(12):e12268.
Article
13. Shirvani MA, Motahari-Tabari N, Alipour A. The effect of mefenamic acid and ginger on pain relief in primary dysmenorrhea: a randomized clinical trial. Arch Gynecol Obstet. 2015; Jun. 291(6):1277–81.
Article
14. Rahnama P, Montazeri A, Huseini HF, Kianbakht S, Naseri M. Effect of Zingiber officinale R. rhizomes (ginger) on pain relief in primary dysmenorrhea: a placebo randomized trial. BMC Complement Altern Med. 2012; Jul. 12:92.
Article
15. Ozgoli G, Goli M, Moattar F. Comparison of effects of ginger, mefenamic acid, and ibuprofen on pain in women with primary dysmenorrhea. J Altern Complement Med. 2009; Feb. 15(2):129–32.
Article
16. Bartels EM, Folmer VN, Bliddal H, Altman RD, Juhl C, Tarp S, et al. Efficacy and safety of ginger in osteoarthritis patients: a meta-analysis of randomized placebo-controlled trials. Osteoarthritis Cartilage. 2015; Jan. 23(1):13–21.
Article
17. Al-Nahain A, Jahan R, Rahmatullah M. Zingiber officinale: a potential plant against rheumatoid arthritis. Arthritis. 2014; 2014:159089. https://doi.org/10.1155/2014/159089.
Article
18. Baugh RF, Archer SM, Mitchell RB, Rosenfeld RM, Amin R, Burns JJ, et al. Clinical practice guideline: tonsillectomy in children. Otolaryngol Head Neck Surg. 2011; Jan. 144(1 Suppl):S1–30.
Article
19. Sutters KA, Isaacson G. Posttonsillectomy pain in children. Am J Nurs. 2014; Feb. 114(2):36–42.
20. Baliga MS, Haniadka R, Pereira MM, D’Souza JJ, Pallaty PL, Bhat HP, et al. Update on the chemopreventive effects of ginger and its phytochemicals. Crit Rev Food Sci Nutr. 2011; Jul. 51(6):499–523.
Article
21. Apariman S, Ratchanon S, Wiriyasirivej B. Effectiveness of ginger for prevention of nausea and vomiting after gynecological laparoscopy. J Med Assoc Thai. 2006; Dec. 89(12):2003–9.
22. Jiang X, Williams KM, Liauw WS, Ammit AJ, Roufogalis BD, Duke CC, et al. Effect of ginkgo and ginger on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects. Br J Clin Pharmacol. 2005; Apr. 59(4):425–32.
Article
23. Lumb AB. Effect of dried ginger on human platelet function. Thromb Haemost. 1994; Jan. 71(1):110–1.
Article
24. Kashefi F, Khajehei M, Alavinia M, Golmakani E, Asili J. Effect of ginger (Zingiber officinale) on heavy menstrual bleeding: a placebo-controlled, randomized clinical trial. Phytother Res. 2015; Jan. 29(1):114–9.
Article
25. Rayati F, Hajmanouchehri F, Najafi E. Comparison of anti-inflammatory and analgesic effects of ginger powder and Ibuprofen in postsurgical pain model: a randomized, double-blind, case-control clinical trial. Dent Res J (Isfahan). 2017; Jan-Feb. 14(1):1–7.
Article
26. Haghighi M, Khalvat A, Toliat T, Jallaei S. Comparing the effects of ginger (Zingiber officinale) extract and Ibuprofen on patients with osteoarthritis. Arch Iran Med. 2005; Oct. 8(4):267–71.
27. Blumenthal M, Busse WR, Goldberg A, Gruenwald J, Hall T, Riggins CW, et al. The complete German commission E monographs: therapeutic guide to herbal medicines. Austin: American Botanical Council;1998.
28. Tiran D. Ginger to reduce nausea and vomiting during pregnancy: evidence of effectiveness is not the same as proof of safety. Complement Ther Clin Pract. 2012; Feb. 18(1):22–5.
Article
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