Ann Surg Treat Res.  2018 Apr;94(4):216-218. 10.4174/astr.2018.94.4.216.

Living donor liver transplantation prior to multiple myeloma treatment in a patient with hepatitis B-associated hepatocellular carcinoma and liver cirrhosis: a case report

  • 1Department of Surgery, Yeungnam University College of Medicine, Daegu, Korea.
  • 2Department of Surgery, Pusan National University Hospital, Busan, Korea.
  • 3Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.


Clinical outcomes of living donor liver transplantation (LDLT) for hepatocellular carcinoma (HCC) in patients with multiple myeloma (MM) have not been established in terms of HCC recurrence and MM deterioration after LDLT. A 51-year-old man with chronic hepatitis B was diagnosed with HCC and MM. Since the patient also had decompensated liver cirrhosis (LC), he underwent LDLT prior to autologous peripheral blood stem cell transplantation (PBSCT) to prevent fulminant hepatitis due to HBV reactivation. The patient received Epstein-Barr virus prophylaxis and a triple immunosuppressive regimen of tacrolimus, everolimus, and steroid after LDLT. Autologous PBSCT was performed 7 months after LDLT. He showed a complete response to treatment of MM without post-LT complications or HCC recurrence. In conclusion, LDLT could be adapted for treatment of MM patients with combined HCC and decompensated LC because it is an effective strategy of preventing HBV reactivation and HCC recurrence after induction therapy of MM.


Living donor liver transplantation; Multiple myeloma; Hepatocellular carcinoma

MeSH Terms

Carcinoma, Hepatocellular*
Hepatitis B, Chronic
Herpesvirus 4, Human
Liver Cirrhosis*
Liver Transplantation*
Living Donors*
Middle Aged
Multiple Myeloma*
Peripheral Blood Stem Cell Transplantation


  • Fig. 1 Bone marrow aspiration (×400): plasma cell proliferation at the time of diagnosis (A), absence of residual plasma cells after autologous peripheral blood stem cell transplantation (B).


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