Lab Anim Res.  2017 Jun;33(2):119-123. 10.5625/lar.2017.33.2.119.

Use of C57BL/6N mice on the variety of immunological researches

Affiliations
  • 1Department of Microbiology and Immunology, INJE University College of Medicine, Busan 47392, Korea. kali71@hanmail.net
  • 2Department of Biomaterials Science, College of Natural Resources & Life Science/Life and Industry Convergence Research Institute, Pusan National University, Miryang 50463, Korea. dyhwang@pusan.ac.kr

Abstract

Inbred mice are an essential animal strain for research as they can improve the reproducibility and reliability of study results. The establishment of new inbred lines is continuing, and new inbred lines are being used in many research fields. C57BL/6 is a mouse laboratory animal that has been developed and used as an inbred strain since early stage of mouse strain development, and, in the 1950s, C57BL/6 was separated into substrains by the Jackson Laboratory (C57BL/6J) and the National Institutes of Health (C57BL/6N). C57BL/6 mice have been used in immunology and antitumor activity studies since the early strain development stage. After the mouse genome was fully described, C57BL/6 mice use in many areas of research has expanded. In particular, immunological characteristics such as those related to cell-mediated immunity and NK cell activity are relatively higher in C57BL/6 mice than in other mice. The C57BL/6NKorl is a stock of C57BL/6N established as part of a localization of experimental animal strategy of the Korean Food and Drug Administration. Based on analysis of single nucleotide polymorphisms (SNPs), C57BL/6NKorl is considered a genetically distinct inbred stock from other C57BL/6N. Various research efforts have been made to describe the characteristics and increase knowledge of the characteristics of C57BL/6Nkorl. The results obtained through these efforts are expected to increase the utilization of C57BL/6Nkorl as a domestic laboratory animal resource and to enhance the reliability of mouse based studies.

Keyword

C57BL/6N; C57BL/6NKorl; inbred strain; laboratory animal resources

MeSH Terms

Allergy and Immunology
Animals
Animals, Laboratory
Genome
Immunity, Cellular
Killer Cells, Natural
Mice*
National Institutes of Health (U.S.)
Polymorphism, Single Nucleotide
United States Food and Drug Administration
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