Endocrinol Metab.  2018 Mar;33(1):33-43. 10.3803/EnM.2018.33.1.33.

Association of Adipokines with Development and Progression of Nonalcoholic Fatty Liver Disease

Affiliations
  • 1Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. nperakak@bidmc.harvard.edu

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease affecting 30% of the general population and 40% to 70% of obese individuals. Adipose tissue plays a crucial role in its pathogenesis, as it produces and secretes pro- and anti-inflammatory cytokines called adipokines. Adiponectin and leptin have well-determined actions in terms of NAFLD pathophysiology. Adiponectin deficiency is associated with a pro-inflammatory condition, as it is observed in obesity and other metabolic disorders. On the other hand, increased leptin levels, above the normal levels, act as a pro-inflammatory stimulus. Regarding other adipokines (resistin, visfatin, chemerin, retinol-binding protein 4, irisin), data about their contribution to NAFLD pathogenesis and progression are inconclusive. In addition, pharmacological agents like thiazolidinediones (pioglitazone and rosiglitazone), that are used in the management of NAFLD exert favourable effects on adipokine levels, which in turn may contribute to the improvement of liver function. This review summarizes the current knowledge and developments in the association between adipokines and NAFLD and discusses possible therapeutic implications targeting the modulation of adipokine levels as a potential tool for the treatment of NAFLD.

Keyword

Non-alcoholic fatty liver disease; Adipokines; Adiponectin; Leptin; Resistin; Nicotinamide phosphoribosyltra; Chemerin; Retinol-binding protein 4

MeSH Terms

Adipokines*
Adiponectin
Adipose Tissue
Cytokines
Hand
Leptin
Liver
Liver Diseases
Nicotinamide Phosphoribosyltransferase
Non-alcoholic Fatty Liver Disease*
Obesity
Resistin
Thiazolidinediones
Adipokines
Adiponectin
Cytokines
Leptin
Nicotinamide Phosphoribosyltransferase
Resistin
Thiazolidinediones
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