Infect Chemother.  2010 Apr;42(2):103-106.

A Case of Oseltamivir-Resistant Pandemic Influenza (H1N1 2009)

Affiliations
  • 1Department of Internal Medicine, Catholic University of Daegu, School of Medicine, Daegu, Korea. heeya0035@cu.ac.kr
  • 2Division of Influenza Virus, Center for Infectious Diseases, National Institute of Health, Centers for Disease Control and Prevention, Seoul, Korea.

Abstract

In April 2009, the first swine origin pandemic influenza (H1N1 2009) infection was reported in Mexico and United states and has since spread rapidly worldwide. Finally on June 11, 2009, WHO officially declared the first pandemic of the 21st century. Until March 2010, more than 213 countries reported laboratory confirmed cases of pandemic influenza H1N1 2009, including at least 16,931 deaths. The drug of choice for treatment and prophylaxis of pandemic (H1N1) 2009 influenza are the neuraminidase inhibitor (oseltamivir and Zanamivir). However, increased use of these drugs lead to the emergence of oseltamivir-resistant strains. We report a case of oseltamivir-resistant pandemic influenza (H1N1 2009) virus infection in a patient who were initially started with oseltamivir for laboratory-confirmed influenza. Patient's symptoms worsened despite the use of high-dose oral oseltamivir, and antiviral susceptibility test showed oseltamivir resistance (H275Y mutation). The patient resolved after treatment with zanamivir.

Keyword

Pandemic; Influenza A; Oseltamivir; Resistance

MeSH Terms

Humans
Influenza, Human
Mexico
Neuraminidase
Oseltamivir
Pandemics
Swine
United States
Viruses
Zanamivir
Neuraminidase
Oseltamivir
Zanamivir

Figure

  • Figure 1 Serial chest radiograph findings. (A) normal chest radiograph at admission, (B) right middle lobe consolidation appears at pandemic influenza (H1N1 2009) diagnosis, (C) sustained right middle lobe consolidation with aggravated right loculated pleural effusion and new patchy consolidation in left upper lobe after 9 day oseltamivir use (D) improved chest radiograph at discharge.

  • Figure 2 Constrast-enhancing chest CT scan at the 9th day of oseltamivir use shows patchy consolidation with centrilobular nodule in right upper lobe, right lower lobe and bilateral pleural effusion.

  • Figure 3 Oseltamivir and amantadine resistant genetic substitution in M2 and NA of pandemic influenza (H1N1 2009) viruses from the patient. (A) Nucleotide sequence TAC (encoding tyrosine) in box exhibits that the viruses contains oseltamivir resistance maker (Y275) on their NA. (B) Nucleotide sequence AAT (coding asparagine) in box exhibits that infected viruses form the patient contains amantadine resistance maker (N31) on their M2. In A and B, single letters and numbers denote abbreviations of individual amino acids and amino acid sequences numbering. respectively.


Reference

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