J Korean Neurol Assoc.  2017 Nov;35(4):211-214. 10.17340/jkna.2017.4.5.

Co-occurrence of Guillain-Barré Syndrome and Acute Disseminated Encephalomyelitis with Dual Positive of Anti-GT1a and Anti-GM1 Antibodies

Affiliations
  • 1Department of Neurology, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea. jongseokbae@hallym.or.kr
  • 2Department of Neurology, Dong-A University Hospital, Dong-A University College of Medicine, Busan, Korea.

Abstract

Acute disseminated encephalomyelitis (ADEM) and Guillain-Barré syndrome (GBS) are both rare post-infectious neurological disorders. The co-existence of these conditions has often been reported despite of low incidence. We describe a 20-year-old male, who presented with acute flaccid paralysis and encephalopathy. The patient showed reversible MRI lesions suggesting ADEM. This case showed anti-GT1a IgG and anti-GM1 IgM antibodies positivity. We suggest that certain immunogenicity within central and peripheral nervous system may share a common autoimmune process during the disease course.

Keyword

Acute disseminated encephalomyelitis; Guillain-Barré syndrome; Gangliosides

MeSH Terms

Antibodies*
Brain Diseases
Encephalomyelitis, Acute Disseminated*
Gangliosides
Guillain-Barre Syndrome*
Humans
Immunoglobulin G
Immunoglobulin M
Incidence
Magnetic Resonance Imaging
Male
Nervous System Diseases
Paralysis
Peripheral Nervous System
Young Adult
Antibodies
Gangliosides
Immunoglobulin G
Immunoglobulin M
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