J Neurocrit Care.  2017 Dec;10(2):126-128. 10.18700/jnc.170025.

Glanzmann Thrombasthenia in a Korean Patient: A Postoperative Intracranial Hemorrhagic Diasthesis in a Patient with a Rupture of a Cerebral Aneurysm

• Choi MS
• Lee JH
• Lim YC

• KMID: 2405769
• DOI: http://doi.org/10.18700/jnc.170025

Abstract

BACKGROUND
Glanzmann thrombasthenia (GT) is a rare disease with severe insufficiency of platelet function. There are no reports of GT associated with a cerebral hemorrhage.
CASE REPORT
A 45-year-old woman had a stuporous mentality. Her computed tomographic (CT) angiography revealed a rupture of the posterior cerebral artery aneurysm. Hunt-Hess grade was 4 points and Fisher grade was 3 points. A clipping of the aneurysm was performed and proceeded to external ventricular drainage for hydrocephalus after 6 days. But, a new hemorrhage was detected several times via a follow-up brain CT. Various blood tests were conducted to evaluate the bleeding tendency, and the GT was diagnosed with PFA-200. The ventriculoperitoneal shunt was performed after the platelets transfusion, and she was discharged without other complications.
CONCLUSION
With nonspecific and recurrent intracranial hemorrhage, a GT should be included in the differential diagnosis, which is important in controlling bleeding during the surgery.

Keyword

Trombastniahe; Postoperative hemorrhages; Aneurysm, Ruptured

MeSH Terms

Aneurysm
Aneurysm, Ruptured
Angiography
Blood Platelets
Brain
Cerebral Hemorrhage
Diagnosis, Differential
Drainage
Female
Follow-Up Studies
Hematologic Tests
Hemorrhage
Humans
Hydrocephalus
Intracranial Aneurysm*
Intracranial Hemorrhages
Middle Aged
Postoperative Hemorrhage
Rare Diseases
Rupture*
Stupor
Thrombasthenia*
Ventriculoperitoneal Shunt