Clin Exp Reprod Med.  2017 Jun;44(2):105-110. 10.5653/cerm.2017.44.2.105.

Mixed double-embryo transfer: A promising approach for patients with repeated implantation failure

• Stamenov G
• Parvanov D
• Chaushev T

• KMID: 2405158
• DOI: http://doi.org/10.5653/cerm.2017.44.2.105

Abstract

OBJECTIVE
The purpose of this study was to evaluate the efficacy of frozen mixed double-embryo transfer (MDET; the simultaneous transfer of day 3 and day 5 embryos) in comparison with frozen blastocyst double-embryo transfer (BDET; transfer of two day 5 blastocysts) in patients with repeated implantation failure (RIF).
METHODS
A total of 104 women with RIF who underwent frozen MDET (n=48) or BDET (n=56) with excellent-quality embryos were included in this retrospective analysis. All frozen embryo transfers were performed in natural cycles. The main outcome measures were the implantation rate, clinical pregnancy rate, multiple pregnancy rate, and miscarriage rate. These measures were compared between the patients who underwent MDET or BDET using the chi-square test or the Fisher exact test, as appropriate.
RESULTS
The implantation and clinical pregnancy rates were significantly higher in patients who underwent MDET than in those who underwent BDET (60.4% vs. 39.3%, p=0.03 and 52.1% vs. 30.4%, p=0.05, respectively). A significantly lower miscarriage rate was observed in the MDET group (6.9% vs. 10.7%, p=0.05). In addition, the multiple pregnancy rate was slightly, but not significantly, higher in the MDET group (27.1% vs. 25.0%).
CONCLUSION
MDET was found to be significantly superior to double blastocyst transfer. It could be regarded as an appropriate approach to improve in vitro fertilization success rates in RIF patients.

Keyword

Miscarriage rate; Mixed double embryo transfer; Pregnancy rate; Repeated implantation failure; Window of implantation

MeSH Terms

Abortion, Spontaneous
Blastocyst
Embryo Transfer
Embryonic Structures
Female
Fertilization in Vitro
Humans
Outcome Assessment (Health Care)
Pregnancy
Pregnancy Rate
Pregnancy, Multiple
Retrospective Studies