Nucl Med Mol Imaging.  2017 Dec;51(4):371-373. 10.1007/s13139-016-0426-9.

Radiation-Induced Giant Cell Granuloma Mimicking Relapsed Hodgkin Lymphoma at FDG-PET/CT

Affiliations
  • 1Department of Radiology and Nuclear Medicine, UniversityMedical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands. h.j.a.adams@gmail.com
  • 2Department of Nuclear Medicine, Meander Medical Center, Amersfoort, The Netherlands.
  • 3Department of Hematology, Meander Medical Center, Amersfoort, The Netherlands.
  • 4Department of Radiology, Meander Medical Center, Amersfoort, The Netherlands.
  • 5Department of Pathology, Meander Medical Center, Amersfoort, The Netherlands.

Abstract

A 22-year-old woman was diagnosed with intermediate risk stage II Hodgkin lymphoma and treated with three cycles of adriamycin, bleomycin, vinblastine, and dacarbazine (ABVD) followed by involved-field radiation therapy. A complete metabolic remission was achieved after two cycles of ABVD, which was maintained until three years after completion of treatment. Follow-up FDG-PET/CT four years after completion of treatment, however, showed a new FDG-avid (Deauville score of 4) lesion in the right scapula, suggesting relapsed disease. Computer tomography (CT)-guided biopsy of this lesion was performed and subsequent histological examination revealed a radiation-induced giant cell granuloma.

Keyword

Biopsy; FDG-PET/CT ; Giant cell granuloma; Hodgkin lymphoma

MeSH Terms

Biopsy
Bleomycin
Dacarbazine
Doxorubicin
Female
Follow-Up Studies
Giant Cells*
Granuloma, Giant Cell*
Hodgkin Disease*
Humans
Scapula
Vinblastine
Young Adult
Bleomycin
Dacarbazine
Doxorubicin
Vinblastine
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