Nucl Med Mol Imaging.  2017 Dec;51(4):360-361. 10.1007/s13139-016-0445-6.

⁶⁸Ga-PSMA PET-CT Imaging of Metastatic Adenoid Cystic Carcinoma

Affiliations
  • 1Department of nuclear medicine and radiology, UMC Utrecht, room E01.132, Heidelberglaan 100, 3584 CX Utrecht, Netherlands. b.dekeizer@umcutrecht.nl
  • 2Department of clinical pharmacy, UMC Utrecht, Utrecht, Netherlands.
  • 3Department of head and neck surgical oncology, UMC Utrecht, Utrecht, Netherlands.
  • 4Department of pathology, UMC Utrecht, Utrecht, Netherlands.

Abstract

A patient with a history of adenoid cystic carcinoma of the nasal cavity presented himself with bone pain and an elevated PSA level. On suspicion of metastatic prostate cancer a ⁶⁸Ga-PSMA PET-CT was performed. The PET-CT showed numerous lung and non-sclerotic bone metastasis. Biopsy of a bone metastasis was performed and pathology showed adenoid cystic carcinoma instead of prostate cancer. Immunohistochemical PSMA staining of the primary tumour showed intense PSMA expression in adenoid cystic carcinoma tumour cells. Because of the high PSMA expression of adenoid cystic carcinoma, ⁶⁸Ga-PSMA PET-CT might be a promising imaging modality for this malignancy.

Keyword

Adenoid Cystic; Carcinoma; (68)Ga-PSMA; Immunohistochemistry; PET-CT

MeSH Terms

Adenoids*
Biopsy
Carcinoma, Adenoid Cystic*
Humans
Immunohistochemistry
Lung
Nasal Cavity
Neoplasm Metastasis
Pathology
Prostatic Neoplasms
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