J Genet Med.  2017 Dec;14(2):49-55. 10.5734/JGM.2017.14.2.49.

Biomarkers and genetic factors for early prediction of pre-eclampsia

  • 1Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University, Seoul, Korea. ogshinyss@chamc.co.kr


Pre-eclampsia is known to cause considerable maternal morbidity and mortality. Thus, many studies have examined the etiopathogenesis of pre-eclampsia. While many pathophysiological factors related to pre-eclampsia have been identified, the precise etiopathogenesis of pre-eclampsia remains unclear. Numerous studies have identified factors for the early prediction for pre-eclampsia to lead to preparation and closer observation on pre-eclampsia when it occurs. This article reviews on current studies of biomarkers and genetic factors related to pre-eclampsia, which may be important for developing strategies for early prediction of pre-eclampsia.


Pre-eclampsia; Biomarkers; Genes; Cell-free nucleic acids; Early detection of disease
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