Nat Prod Sci.  2017 Dec;23(4):291-298. 10.20307/nps.2017.23.4.291.

Cytotoxicity and Structure Activity Relationship of Dammarane-Type Triterpenoids from the Bark of Aglaia elliptica against P-388 Murine Leukemia Cells

• Hidayat AT
• Farabi K
• Harneti D
• Maharani R
• Darwati
• Nurlelasari
• Mayanti T
• Setiawan A
• Supratman
• Shiono Y

• KMID: 2401583
• DOI: http://doi.org/10.20307/nps.2017.23.4.291

Abstract

Six dammarane-type triterpenoids, dammar-24-en-3β-ol (1), 3β-epicabraleahydroxy lactone (2), (E)-25-hydroperoxydammar-23-en-3β,20-diol (3), dammar-24-en-3β,20-diol (4), 3β-acetyl-20S,24S-epoxy-25-hydroxydammarane (5), and 3β-epiocotillol (6) were isolated from the methanolic extract of the bark of Aglaia elliptica. The chemical structure were identified on the basis of spectroscopic evidence and by comparison with those spectra previously reported. Compounds 1 - 6 were isolated first time from this plant. Compounds 1 - 6, along with a known synthetic analog, cabraleone (7) were evaluated their cytotoxic activity against P-388 murine leukimia cells in vitro. Among those compounds 3β-acetyl-20S,24S-epoxy-25-hydroxydammarane (5) showed strongest cytotoxic activity with ICâ‚…â‚€ value of 8.02 ± 0.06 µM.

Keyword

Dammarane-type Triterpenoids; Aglaia elliptica; Meliaceae; P-388 murine leukimia cell

MeSH Terms

Aglaia*
In Vitro Techniques
Leukemia*
Meliaceae
Methanol
Plants
Structure-Activity Relationship*
Methanol

Figure

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  Fig. 1. The structures of 1 – 7 isolated from A. elliptica.

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  Fig. 2. Key HMBC (→) and COSY (−) correlations of 1 – 6.

Reference

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