Ann Pediatr Endocrinol Metab.  2017 Dec;22(4):259-265. 10.6065/apem.2017.22.4.259.

Treatment outcomes of gonadotropin-releasing hormone agonist in obese girls with central precocious puberty

• Kim HR
• Nam HK
• Rhie YJ
• Lee KH

• KMID: 2400783
• DOI: http://doi.org/10.6065/apem.2017.22.4.259

Abstract

PURPOSE
This study investigated the influence of obesity on the clinical course and effect of gonadotropin-releasing hormone analog (GnRHa) treatment in girls with central precocious puberty (CPP).
METHODS
Medical records of 182 girls with CPP treated with GnRHa were reviewed. They were divided into 2 groups: normal weight (n=108) and overweight/obesity (n=74). Chronological age (CA), bone age (BA), difference between BA and CA (BA-CA), standard deviation score (SDS) of height, body mass index (BMI), predicted adult height (PAH), and laboratory findings were compared at baseline, after 1 year, and at the end of GnRHa treatment in both groups.
RESULTS
Mean BMI SDS at baseline was 0.08±0.60 in the normal weight group and 1.55±0.36 in the overweight/obesity group. Initial CA, BA, midparental height, and PAH were similar between the 2 groups. BA-CA after treatment was significantly decreased compared to baseline in both groups (P < 0.001). Between the 2 groups, a decrease in BA-CA during treatment showed no significant difference. PAH at the end of treatment was significantly increased compared to baseline in both groups (P < 0.001). PAH at the end of treatment in the overweight/obesity group (159.88±3.41 cm) was similar to that of the normal weight group (159.19±3.25 cm). Comparing the 2 groups according to change in BMI after treatment, there were no differences in ΔPAH, ΔBA-CA, and Δheight SDS for BA.
CONCLUSIONS
GnRHa treatment in obese girls with CPP improved the height outcome and had similar results in normal weight CPP girls. Obesity might not affect the efficacy of GnRHa in girls with CPP.

Keyword

Central precocious puberty; Overweight; Obesity; Gonadotropin-releasing hormone agonist

MeSH Terms

Adult
Body Height
Female*
Gonadotropin-Releasing Hormone*
Humans
Medical Records
Obesity
Overweight
Puberty, Precocious*
Gonadotropin-Releasing Hormone

Figure

• 

  Fig. 1. Changes in treatment-effect parameters during gonadotropin-releasing hormone agonist treatment. BA–CA (A), height SDS for CA (B), and height SDS for BA (C). BA, bone age; CA, chronological age; BA–CA, difference between BA and CA; SDS, standard deviation score. *P<0.001 compared to baseline of treatment.

• 

  Fig. 2. Changes in the BMI SDS during gonadotropin-releasing hormone agonist treatment. BMI, body mass index; SDS, standard deviation score. * P<0.001 compared to baseline of treatment.

Reference

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