J Periodontal Implant Sci.  2017 Dec;47(6):381-387. 10.5051/jpis.2017.47.6.381.

Ridge preservation using basic fibroblast growth factor-2 and collagenated biphasic calcium phosphate in beagle dogs

Affiliations
  • 1Department of Periodontology, Dental Research Institute, Seoul National University School of Dentistry, Seoul, Korea. kst72@snu.ac.kr
  • 2Department of Restorative Dentistry, University at Buffalo School of Dental Medicine, Buffalo, NY, USA.

Abstract

PURPOSE
The aim of this study was to evaluate volumetric and histologic changes in edentulous alveolar ridge areas after ridge preservation using basic fibroblast growth factor-2 (bFGF-2) in combination with collagenated biphasic calcium phosphate (BCP).
METHODS
The experiments were performed in 6 adult male beagle dogs. The following 3 groups were created: 1) ridge preservation with bFGF-2 and collagenated BCP (experimental group), 2) ridge preservation with collagenated BCP (positive control group), and 3) a negative control group in which no ridge preservation procedure was performed. Volumetric change analysis was performed using an optical scanner and casts. Histological observations were made using light microscopy.
RESULTS
After the initial swelling subsided, the magnitude of the volumetric change in the experimental group and positive control group was smaller than in the negative control group. In the experimental group, a distinct trend was observed for the resorption of residual bone and collagen fibers at 4 weeks and for more mature bone and faster healing at 12 weeks.
CONCLUSIONS
Based on the findings of the present study, bFGF-2 may be considered for use as a therapeutic molecule in ridge preservation procedures.

Keyword

Alveolar process; Fibroblast growth factors; Hydroxyapatite-beta tricalcium phosphate; Tooth extraction

MeSH Terms

Adult
Alveolar Process
Animals
Calcium*
Collagen*
Dogs*
Fibroblast Growth Factor 2*
Fibroblast Growth Factors
Fibroblasts*
Humans
Male
Microscopy
Tooth Extraction
Calcium
Collagen
Fibroblast Growth Factor 2
Fibroblast Growth Factors
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