J Periodontal Implant Sci.  2017 Dec;47(6):363-371. 10.5051/jpis.2017.47.6.363.

A randomized controlled clinical study of periodontal tissue regeneration using an extracellular matrix-based resorbable membrane in combination with a collagenated bovine bone graft in intrabony defects

• Kim S
• Chang H
• Hwang JW
• Kim S
• Koo KT
• Kim TI
• Seol YJ
• Lee YM
• Ku Y
• Lee JH
• Rhyu IC

• KMID: 2399742
• DOI: http://doi.org/10.5051/jpis.2017.47.6.363

Abstract

PURPOSE
The purpose of this study was to investigate the feasibility of regenerative therapy with a collagenated bone graft and resorbable membrane in intrabony defects, and to evaluate the effects of the novel extracellular matrix (ECM)-based membrane clinically and radiologically.
METHODS
Periodontal tissue regeneration procedure was performed using an ECM-based resorbable membrane in combination with a collagenated bovine bone graft in intrabony defects around the teeth and implants. A novel extracellular matrix membrane (NEM) and a widely-used membrane (WEM) were randomly applied to the test group and the control group, respectively. Cone-beam computed tomography images were obtained on the day of surgery and 6 months after the procedure. Alginate impressions were taken and plaster models were made 1 week and 6 months postoperatively.
RESULTS
The quantity of bone tissue, the dimensional changes of the surgically treated intrabony defects, and the changes in width and height below the grafted bone substitutes showed no significant difference between the test and control groups at the 6-month examination.
CONCLUSIONS
The use of NEM for periodontal regeneration with a collagenated bovine bone graft showed similar clinical and radiologic results to those obtained using WEM.

Keyword

Bone regeneration; Bone substitutes; Cone-beam computed tomography; Guided tissue regeneration; Three-dimensional imaging

MeSH Terms

Bone and Bones
Bone Regeneration
Bone Substitutes
Clinical Study*
Collagen*
Cone-Beam Computed Tomography
Extracellular Matrix
Guided Tissue Regeneration
Imaging, Three-Dimensional
Membranes*
Regeneration*
Tooth
Transplants*
Bone Substitutes
Collagen

Figure

• 

  Figure 1 Flow diagram for the phases of the randomized controlled trial. CBCT: cone-beam computed tomography, VAS: visual analog scale.

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  Figure 2 Superimposition of the impression model scans at 1 week and 6 months post-operation.

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  Figure 3 Sagittal CBCT images of the mesial intrabony defect of the upper left canine tooth obtained immediately after the operation and 6 months postoperatively. The filled bone substitutes can be observed on the CBCT image taken immediately after the operation, and were well integrated with the surrounding bone tissue at 6 months. (A) CBCT image obtained on the day of surgery. (B) CBCT image obtained 6 months after the operation. CBCT: cone-beam computed tomography.

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