Infect Chemother.  2017 Dec;49(4):268-274. 10.3947/ic.2017.49.4.268.

Human Immunodeficiency Virus (HIV) and Hepatitis Virus Coinfection among HIV-Infected Korean Patients: The Korea HIV/AIDS Cohort Study

Affiliations
  • 1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. seran@yuhs.ac
  • 2Division of Infectious Disease, Department of Internal Medicine, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.
  • 3Division of Infectious Disease, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
  • 4Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea.
  • 5Department of Internal Medicine, Inha University School of Medicine, Incheon, Korea.
  • 6Department of Preventive Medicine, Hanyang University College of Medicine, Seoul, Korea.
  • 7Institute for Health and Society, Hanyang University, Seoul, Korea.
  • 8Korea Centers for Disease Control and Prevention, Cheongju, Korea.

Abstract

BACKGROUND
Despite declines in mortality and morbidity rates of patients with human immunodeficiency virus (HIV) infection as the result of highly active antiretroviral therapy, liver diseases due to chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are a leading cause of death among HIV-infected patients. However, HIV and HBV or HCV coinfection is still poorly documented, and more information is needed to better understand the characteristics of HIV-infected patients in Korea.
MATERIALS AND METHODS
A cross-sectional study was performed to investigate clinical characteristics and prevalence of HBV and HCV infection in HIV patients enrolled in the Korea HIV/acquired immune deficiency syndrome (AIDS) cohort study from 17 institutions between December 2006 and July 2013.
RESULTS
Among the 1,218 HIV-infected participants, 541 were included in this study. The prevalence of HBV-HIV and HCV-HIV coinfection was 5.0% (27/541) and 1.7% (9/541), respectively. There was no patient who was positive for both HBs antigen and HCV antibody. In multivariate logistic regression analysis, HBV unvaccinated status was a significant risk factor for HBV-HIV coinfection (odds ratio = 4.95, 95% confidence interval = 1.43-17.13).
CONCLUSIONS
HBV and HCV infection was more common in HIV-infected persons enrolled in the Korean HIV/AIDS cohort, than in the general population in Korea.

Keyword

HIV infection; Hepatitis B virus; Hepatitis C virus; Coinfection

MeSH Terms

Antiretroviral Therapy, Highly Active
Cause of Death
Cohort Studies*
Coinfection*
Cross-Sectional Studies
Hepacivirus
Hepatitis B virus
Hepatitis B, Chronic
Hepatitis Viruses*
Hepatitis*
HIV Infections
HIV*
Humans*
Korea*
Liver Diseases
Logistic Models
Mortality
Prevalence
Risk Factors

Figure

  • Figure 1 Profile of enrolled patients. ART, antiretroviral therapy; RNA, ribonucleic acid; BMI, body mass index; AST, aspartate transaminase; ALT, alanine transaminase; HIV, human immunodeficiency virus; HBV, hepatitis B virus; HCV, hepatitis C virus.


Cited by  2 articles

Significance of Decreasing Rate of HIV and HBV Co-infection in a Nationwide Korean HIV/AIDS Cohort
Yoonjung Kim, Shin-Woo Kim, Ki Tae Kwon, Hyun-Ha Chang, Yoonhee Jun, Jang Wook Sohn, Dae Won Park, Joon Young Song, Jun Yong Choi, Hyo Youl Kim, June Myung Kim, Bo Youl Choi, Yunsu Choi, Mee-Kyung Kee, Myeong Su Yoo, Jung Gyu Lee
J Korean Med Sci. 2020;35(3):.    doi: 10.3346/jkms.2020.35.e7.

Clinical Characteristics and Treatment Outcomes of Patients with Hepatitis C Virus and Human Immunodeficiency Virus Coinfection: Experience at a Single Center in Korea
Dae Hyun Lim, Jae Yoon Jeong, Seongwoo Nam, Jongkyoung Choi, Hyeok Choon Kwon, Yong Bum Yoon, Yeonjae Kim, BumSik Chin
J Korean Med Sci. 2021;36(46):e308.    doi: 10.3346/jkms.2021.36.e308.


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