J Korean Orthop Assoc.  2004 Sep;39(5):586-588.

Generalized Tonic-Clonic Seizure following Myelography with Iohexol (Omnipaque.): A Case Report

• Song KJ
• Lee KB

Abstract

We encountered a patient who had a rare occurrence of a seizure after lumbar myelography from the beginning of this untoward side effect. Clinical trials with iohexol in myelography have demonstrated a good tolerability of this water-soluble contrast medium. However, there have been a few reports that have shown acute adverse reactions such as headaches, vomiting, psychosis, confusion and generalized tonic-clonic seizures. Despite the reports on the safety of iohexol use, it may cause a generalized seizure attack without an epileptogenic history. Therefore, thorough attention and the preparation for emergency treatments for the seizure are essential in every myelography using iohexol as a contrast medium. Moreover, in order to avoid unwanted legal problems, the patients and their family need to be informed of the necessity and possible side effects associated with myelography.

Keyword

Myelogram; Seizure; Iohexol

MeSH Terms

Emergency Treatment
Headache
Humans
Iohexol*
Myelography*
Psychotic Disorders
Seizures*
Vomiting
Iohexol