J Vet Sci.  2017 Dec;18(4):555-558. 10.4142/jvs.2017.18.4.555.

Use of stem-cell sheets expressing bone morphogenetic protein-7 in the management of a nonunion radial fracture in a Toy Poodle

  • 1Department of Veterinary Surgery, College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon 24341, Korea. bjkang@kangwon.ac.kr
  • 2Department of Veterinary Surgery, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea.


A 12-year-old castrated Toy Poodle was referred to the Kangwon National University Animal Hospital with an oligotrophic nonunion fracture in the distal 1/3 of the left radius and an intact ulna. After fixation by a locking plate and screws, adipose-derived mesenchymal stem-cell sheets expressing bone morphogenetic protein 7 (BMP-7) were transplanted to the fracture site to enhance the healing activity. The fracture was healed at 9 weeks after surgery. In the present case, the mesenchymal stem-cell sheets expressing BMP-7 promoted bone regeneration and healing in a nonunion fracture.


adipose-derived mesenchymal stromal cells; bone morphogenetic protein 7; dogs; ununited fractures
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