Korean J Thorac Cardiovasc Surg.
2017 Dec;50(6):471-473. 10.5090/kjtcs.2017.50.6.471.
Carney Complex: Eleven Open Heart Operations in a Single Family
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- 1Department of Thoracic and Cardiovascular Surgery, Chungnam National University School of Medicine, Korea. ts7378@cnuh.co.kr
- KMID: 2398382
- DOI: http://doi.org/10.5090/kjtcs.2017.50.6.471
Abstract
- Herein, we report on a family with Carney complex. Four members of the family underwent a total of 11 open heart operations as well as 9 other operations to treat extrathoracic masses. All the family members met at least 2 major clinical criteria and 1 supplemental criterion. We analyzed their genomic loci, including the protein kinase A regulatory subunit 1 gene. The results revealed no specific mutations, except for a common single nucleotide polymorphism. This case series of Carney complex emphasizes the importance of close longitudinal follow-up because of the high rate of tumor recurrence irrespective of the site. Clinicians should not overlook the specific features of familial myxoma.
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