Imaging Sci Dent.  2017 Dec;47(4):281-284. 10.5624/isd.2017.47.4.281.

Magnetic resonance imaging appearance of foreign-body granulomatous reactions to dermal cosmetic fillers

Affiliations
  • 1Department of Radiology and Orthodontics, School of Dentistry, University City of Sao Paulo, Sao Paulo, Brazil.
  • 2Division of Oral and Maxillofacial Pathology, Department of Stomatology, School of Dentistry, University of Sao Paulo, Sao Paulo, Brazil.
  • 3Division of General Pathology, Department of Stomatology, School of Dentistry, University of Sao Paulo, Sao Paulo, Brazil. pbraz@usp.br
  • 4Division of Radiology, Department of Stomatology, School of Dentistry, University of Sao Paulo, Sao Paulo, Brazil.
  • 5Laboratory of Virology, Institute of Tropical Medicine of Sao Paulo, University of Sao Paulo, Sao Paulo, Brazil.

Abstract

Foreign body granulomas can develop after the injection of various cosmetic filling materials into the facial area to flatten wrinkles. Clinically, reactive lesions are easily mistaken for soft-tissue neoplasms or cysts. This report presents a case of foreign body granuloma in a 52-year-old female patient complaining of a painless swelling in the nasolabial region. Both clinical and histological features are described, underscoring the diagnostic role of magnetic resonance imaging findings.

Keyword

Magnetic Resonance Imaging; Granuloma, Foreign-Body; Dermal Filllers

MeSH Terms

Female
Granuloma, Foreign-Body
Humans
Magnetic Resonance Imaging*
Middle Aged

Figure

  • Fig. 1 Swelling and mild redness is seen of the right nasolabial fold.

  • Fig. 2 A. An axial T2-weighted MR image shows a cluster of low-intensity fluid collection. B. A coronal T1-weighted spectral pre-saturation with inversion recovery (SPIR) image with contrast surrounded by a thin hypo-intense capsule in the nasolabial fold. C. A T1-weighted sagittal image reveals an iso-hypointense collection.

  • Fig. 3 Histopathological view (hematoxylin and eosin stain; original magnification A. 100×. B. 400×): A well-circumscribed granulomatous reaction without necrosis, showing a large number of multinucleated giant cells with peripheral disposition of the nuclei associated with areas without substance, indicating foreign body particles (*).


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