Asia Pac Allergy.  2015 Jan;5(1):40-46. 10.5415/apallergy.2015.5.1.40.

Tolerance to etoricoxib in children with nonsteroidal anti-inflammatory drug hypersensitivity

Affiliations
  • 1Allergy Service, Department of Pediatric Medicine, KK Women's and Children's Hospital, Singapore 229899, Singapore. loh.wenyin@kkh.com.sg

Abstract

BACKGROUND
Cyclooxygenase-2 (COX-2) inhibitors have been found to be safe alternatives in adults with cross-intolerant hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs). However they are usually not prescribed in children and there is little information about their tolerance in the pediatric age group.
OBJECTIVE
This study aims to evaluate the tolerance to etoricoxib in children with hypersensitivity to multiple antipyretics.
METHODS
A retrospective case series of children diagnosed with hypersensitivity reactions to NSAIDs and/or paracetamol who underwent a drug provocation test (DPT) with etoricoxib. Information on atopy, family history of allergic diseases, and medication usage was collected. Outcomes of the DPTs and tolerance to etoricoxib were also evaluated.
RESULTS
A total of 24 children, mean age 13.5 years, had a diagnosis of cross-intolerant hypersensitivity to NSAIDs and/or paracetamol. All except one patient successfully tolerated an oral challenge with etoricoxib. Of those who passed the DPT, the majority continued to use etoricoxib with no problems. It was found to be moderately effective in reducing fever and pain.
CONCLUSION
Etoricoxib can be used as a safe alternative in older children with hypersensitivity to multiple antipyretics.

Keyword

Child; Cyclooxygenase-2; Hypersensitivity; Anti-inflammatory agents, Non-steroidal; Acetaminophen

MeSH Terms

Acetaminophen
Adult
Anti-Inflammatory Agents, Non-Steroidal
Antipyretics
Child*
Cyclooxygenase 2
Diagnosis
Drug Hypersensitivity*
Fever
Humans
Hypersensitivity
Retrospective Studies
Acetaminophen
Anti-Inflammatory Agents, Non-Steroidal
Antipyretics
Cyclooxygenase 2
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